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Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy

文献类型：期刊论文

作者Guo, Linmiao3,4; Miao, Yunqiu2,4; Wang, Ying3,4; Zhang, Ying3,4; Zhou, Erfen1; Wang, Jiangyue4; Zhao, Yanqi3,4; Li, Lijun3,4; Wang, Aohua3,4; Gan, Yong3,4
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2022-10-28
页码15
关键词atherosclerosis biomimetic nanovesicles comprehensive therapies lipidated peptides macrophage membranes
ISSN号1616-301X
DOI10.1002/adfm.202204822
通讯作者Gan, Yong(ygan@simm.ac.cn) ; Zhang, Xinxin(xinxinzhang@simm.ac.cn)
英文摘要Atherosclerosis is the underlying cause for cardiovascular disease. Current pharmacotherapies are limited by the inadequate targeting and insufficient treatment. Herein, inspired by the interaction of macrophage and lipoprotein as a typical hallmark of atherosclerosis, hybrid nanovesicles (MLP-NVs) are designed by fusion of anti-inflammatory M2-phenotype macrophage membranes and lipidated peptide (DOPE-pp-HBSP) to mimic the binding manner of cell-lipoprotein for atherosclerotic treatment. Through hybridization of M2 macrophage membranes and lipidated peptide film, MLP-NVs facilitate the inflammatory cell internalization at atherosclerotic site, and sequester the proinflammatory cytokines to suppress local inflammation. Moreover, MLP-NVs exhibit a matrix metalloprotease 2 (MMP2)-responsive release of the peptide HBSP in plaques, leading to the restoration of dysfunctional endothelial cells. In the ApoE(-/-) mice with atherosclerosis, simvastatin-loaded MLP-NVs provide comprehensive treatment by inherent inflammation suppression, endothelial repair, and cholesterol efflux capacities, resulting in atherosclerotic plaques regression. Through closely mimicking physiological cues, this biomimetic hybrid nanovesicle platform provides a potential strategy for anti-atherosclerotic therapy.
WOS关键词NON-RESOLVING INFLAMMATION ; CELLS ; NANOPARTICLES
资助项目Natural Science Foundation of Shanghai[21ZR1475800] ; National Natural Science Foundation of China[82222066] ; National Natural Science Foundation of China[81973250] ; National Natural Science Foundation of China[82104113] ; State Key Laboratory of Drug Research[SIMM2103ZZ-01]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000875461800001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/303148]  
专题新药研究国家重点实验室
通讯作者Gan, Yong; Zhang, Xinxin
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210046, Peoples R China
2.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Shanghai 200072, Peoples R China
3.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Linmiao,Miao, Yunqiu,Wang, Ying,et al. Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2022:15.
APA Guo, Linmiao.,Miao, Yunqiu.,Wang, Ying.,Zhang, Ying.,Zhou, Erfen.,...&Zhang, Xinxin.(2022).Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy.ADVANCED FUNCTIONAL MATERIALS,15.
MLA Guo, Linmiao,et al."Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy".ADVANCED FUNCTIONAL MATERIALS (2022):15.

入库方式： OAI收割

来源：上海药物研究所

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