Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives
文献类型：期刊论文
| 作者 | Li, Jiao4,5; Cai, Zhenyu3; Li, Xu-Wen1,2 ; Zhuang, Chunlin4,5
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| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
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| 出版日期 | 2022-10-07 |
| 页码 | 28 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/acs.jmedchem.2c01223 |
| 通讯作者 | Li, Xu-Wen(zclnathan@163.com) ; Zhuang, Chunlin(xwli@simm.ac.cn) |
| 英文摘要 | Targeted protein degradation (TPD), a promising therapeutic strategy in drug discovery, has great potential to regulate the endogenous degradation of undruggable targets with small molecules. As vital resources that provide diverse structural templates for drug discovery, natural products (NPs) are a rising and robust arsenal for the development of therapeutic TPD. The first proof-of-concept study of proteolysis-targeting chimeras (PROTACs) was a natural polyketide ovalicin-derived degrader; since then, NPs have shown great potential to promote TPD technology. The use of NP-inspired targeted protein degraders has been confirmed to be a promising strategy to treat many human conditions, including cancer, inflammation, and nonalcoholic fatty liver disease. Nevertheless, the development of NP-inspired degraders is challenging, and the field is currently in its infancy. In this review, we summarize the bioactivities and mechanisms of NP-inspired degraders and discuss the associated challenges and future opportunities in this field. |
| WOS关键词 | PSEUDOLARIC ACID-B ; ARYL-HYDROCARBON RECEPTOR ; SMALL MOLECULES ; RETINOIC-ACID ; BARDOXOLONE METHYL ; CHIMERIC MOLECULES ; CELL-DEATH ; DEGRADATION ; DESIGN ; DISCOVERY |
| 资助项目 | National Key R&D Program of China[2021YFA1302200] ; National Key R&D Program of China[2021YFF0502400] ; National Natural Science Foundation of China[82022065] ; National Natural Science Foundation of China[82022069] ; National Natural Science Foundation of China[82204266] ; Shanghai Shuguang Program[21SG38] ; Science and Technology Commission of Shanghai Municipality[21S11900800] ; SMMU Sanhang Program |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000875690300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303154]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Xu-Wen; Zhuang, Chunlin |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Tongji Univ, Tongji Univ Canc Ctr, Shanghai Peoples Hosp 10, Sch Med, Shanghai 200092, Peoples R China 4.Second Mil Med Univ, Sch Pharm, Shanghai 200433, Shanghai, Peoples R China 5.Tongji Univ, Shanghai Peoples Hosp 10, Clin Med Sci & Tech Innovat Ctr, Sch Med, Shanghai 200072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jiao,Cai, Zhenyu,Li, Xu-Wen,et al. Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives[J]. JOURNAL OF MEDICINAL CHEMISTRY,2022:28. |
| APA | Li, Jiao,Cai, Zhenyu,Li, Xu-Wen,&Zhuang, Chunlin.(2022).Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives.JOURNAL OF MEDICINAL CHEMISTRY,28. |
| MLA | Li, Jiao,et al."Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives".JOURNAL OF MEDICINAL CHEMISTRY (2022):28. |
入库方式： OAI收割
来源：上海药物研究所
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