cis-Clerodane Diterpenoids with Structural Diversity and Anti-inflammatory Activity from Tinospora crispa
文献类型：期刊论文
| 作者 | You, Jin-Qiu3; Liu, Yi-Nan1,3; Zhou, Jun-Su1; Sun, Xin-Yu1; Lei, Chun3; Mu, Qing3; Li, Jing-Ya1 ; Hou, Ai-Jun2,3
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| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2022-10-22 |
| 页码 | 11 |
| 关键词 | Natural products Structure elucidation Tinospora crispa ATP-citrate lyase Nuclear factor kappa B |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.202200433 |
| 通讯作者 | Mu, Qing(muqing@fudan.edu.cn) ; Li, Jing-Ya(jyli@simm.ac.cn) ; Hou, Ai-Jun(ajhou@shmu.edu.cn) |
| 英文摘要 | Comprehensive Summary Twelve new cis-clerodane diterpenoids, designated as crispinoids A-L (1-12), together with three known analogues (13-15), were isolated from Tinospora crispa. Their structures were fully assigned by comprehensive spectroscopic techniques, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) analyses. The isolated clerodanes displayed diverse heterocyclic frameworks including 6/6/6-, 6/5/6/6-, 6/6/5-, 6/6-, and 6/5/6-fused ring systems. Some of the isolates showed ATP-citrate lyase (ACLY) and nuclear factor kappa B (NF-kappa B) pathway inhibition. The NF-kappa B inhibitors further suppressed the lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 cells. |
| WOS关键词 | TUBERCULATA BEUMEE ; FURANODITERPENOIDS ; CONSTITUENTS |
| 资助项目 | National Natural Science Foundation of China[22277074] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000871088900001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303223]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Mu, Qing; Li, Jing-Ya; Hou, Ai-Jun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China 3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | You, Jin-Qiu,Liu, Yi-Nan,Zhou, Jun-Su,et al. cis-Clerodane Diterpenoids with Structural Diversity and Anti-inflammatory Activity from Tinospora crispa[J]. CHINESE JOURNAL OF CHEMISTRY,2022:11. |
| APA | You, Jin-Qiu.,Liu, Yi-Nan.,Zhou, Jun-Su.,Sun, Xin-Yu.,Lei, Chun.,...&Hou, Ai-Jun.(2022).cis-Clerodane Diterpenoids with Structural Diversity and Anti-inflammatory Activity from Tinospora crispa.CHINESE JOURNAL OF CHEMISTRY,11. |
| MLA | You, Jin-Qiu,et al."cis-Clerodane Diterpenoids with Structural Diversity and Anti-inflammatory Activity from Tinospora crispa".CHINESE JOURNAL OF CHEMISTRY (2022):11. |
入库方式： OAI收割
来源：上海药物研究所
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