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ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity

文献类型：期刊论文

作者Wang, Jiaoying5,6; Li, Jie5; Wu, Yao3,4; Xu, Xiaoxuan5; Qian, Xindi5; Lei, Ying2; Liu, Huanzhen2; Zhang, Zhiwen3,4; Li, Yaping1,5,6
刊名NANO LETTERS
出版日期2022-10-13
页码9
ISSN号1530-6984
关键词ROS-responsive PD-L1 cabazitaxel tumor penetration antitumor immunity
DOI10.1021/acs.nanolett.2c03227
通讯作者Zhang, Zhiwen(zhangzhiwen@fudan.edu.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Despite the promising benefits of immune checkpoint inhibitors (ICIs) in clinical cancer treatments, the therapeutic efficacy is largely restricted by low antitumor immunity and limited intratumor delivery in solid tumors. Herein, we designed a reactive oxygen species (ROS)-responsive albumin nanocomplex of antiprogrammed cell death receptor ligand 1 (aPD-L1) and cabazitaxel (RAN-PC), which exhibited prominent tumor accumulation and intratumor permeation in 4T1 tumors. Compared with the negative control, the RAN-PC + radiation treatment (RAN-PC+X) produced a 3.61-and 5.10-fold enhance-ment in CD3+CD8+ T cells and the interferon (IFN)-gamma-expressing subtype, respectively, and notably reduced versatile immunosup-pressive cells. Moreover, RAN-PC+X treatment resulted in notable retardation of tumor growth, with a 78.97% inhibition in a 4T1 breast tumor model and a 90.30% suppression in a CT-26 colon tumor model. Therefore, the ROS-responsive albumin nanocomplex offers an encouraging platform for ICIs with prominent intratumor delivery capacity for cancer immunotherapy.
WOS关键词IMMUNOGENIC CELL-DEATH ; I EXPRESSION ; CANCER ; NANOMEDICINE ; PENETRATION ; PROMOTES
资助项目National Natural Science Foundation of China ; Shandong Province Natural Science Foundation ; International Partnership Program of Chinese Academy of Sciences ; [32071385] ; [32271461] ; [32130058] ; [31930066] ; [ZR2019ZD25] ; [153631KYSB20190013]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000870992600001
源URL[http://119.78.100.183/handle/2S10ELR8/303226]  
专题新药研究国家重点实验室
通讯作者Zhang, Zhiwen; Li, Yaping
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
2.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies SIAIS, Shanghai 201210, Peoples R China
3.Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China
4.Fudan Univ, Sch Pharm, Minist Educ, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
6.Shanghai Univ, Sch Environm Chem & Engn, Shanghai 200444, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Jiaoying,Li, Jie,Wu, Yao,et al. ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity[J]. NANO LETTERS,2022:9.
APA Wang, Jiaoying.,Li, Jie.,Wu, Yao.,Xu, Xiaoxuan.,Qian, Xindi.,...&Li, Yaping.(2022).ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity.NANO LETTERS,9.
MLA Wang, Jiaoying,et al."ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity".NANO LETTERS (2022):9.

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来源：上海药物研究所

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