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Naphthoquinones and triterpenoids from Arnebia euchroma (Royle) Johnst and their hypoglycemic and lipid-lowering effects

文献类型：期刊论文

作者Tan, Yuqi3,4; Tian, Danmei3,4; Li, Cong2; Chen, Yanhui3,4; Shen, Yiran2; Li, Jia1,2; Tang, Jinshan3,4
刊名FITOTERAPIA
出版日期2022-10-01
卷号162页码:8
关键词Arnebia euchroma (Royle) Johnst Naphthoquinone Triterpenoid Hypoglycemic and lipid-lowering effects Cytotoxicity
ISSN号0367-326X
DOI10.1016/j.fitote.2022.105288
通讯作者Tang, Jinshan(gztangjinshan@126.com)
英文摘要A new pentacyclic triterpenoid, 2-hydroxy-1-ene-hydroxyhopanone (19), and a new benzoxepin-5-one, 3-(4methyl-3-penten-1-yl)-6-hydroxy-9-methoxy-2H-1-benzoxepin-5-one (25), along with 26 known compounds (1-18, 20-24, 26-28), were isolated from the roots of Arnebia euchroma (Royle) Johnst. The structures of the new compounds were elucidated by extensive spectroscopic analyses. The absolute configurations of shikonofurans 9-13 were determined by quantum chemical ECD calculations and CD spectra comparison for the first time. Pharmacological study revealed that naphthoquinones 1-5, 7, and 8 had obvious cytotoxicity toward human lung adenocarcinoma A549 cell line. Meanwhile, the hypoglycemic and lipid-lowering effects of isolated compounds were assessed by checking their inhibitory effects on key enzymes regulating glucose and lipid metabolism. Results showed that compounds 1, 3, 5, 6, 8, 18, and 19 could inhibit the activity of ATP-citrate lyase (ACL); compound 7 could inhibit the activity of acetyl-CoA carboxylase (ACC1); while compounds 8 and 19 showed inhibitory effects on protein tyrosine phosphatase 1B (PTP1B). Among them, the naphthoquinone 6, steroid 18, and triterpenoid 19 showed moderate inhibitory effects on ACL and PTP1B, but didn't exhibit obvious cytotoxicity. This study demonstrated that compounds 6, 18, and 19 show great promising for the development of new agents for the treatment of metabolic diseases.
WOS关键词BIOLOGICALLY-ACTIVE CONSTITUENTS ; LITHOSPERMUM-ERYTHRORHIZON ; SHIKONIN ; DERIVATIVES ; IDENTIFICATION ; PURIFICATION ; INHIBITION
资助项目Guangdong Basic and Applied Basic Research Foundation ; National 111 Project of China ; High Performance Public Computing Service Platform of Jinan University ; [2021A1515011244] ; [B13038]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000870866700001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/303229]  
专题新药研究国家重点实验室
通讯作者Tang, Jinshan
作者单位1.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Shandong, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Peoples R China
4.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Peoples R China
推荐引用方式
GB/T 7714		 Tan, Yuqi,Tian, Danmei,Li, Cong,et al. Naphthoquinones and triterpenoids from Arnebia euchroma (Royle) Johnst and their hypoglycemic and lipid-lowering effects[J]. FITOTERAPIA,2022,162:8.
APA Tan, Yuqi.,Tian, Danmei.,Li, Cong.,Chen, Yanhui.,Shen, Yiran.,...&Tang, Jinshan.(2022).Naphthoquinones and triterpenoids from Arnebia euchroma (Royle) Johnst and their hypoglycemic and lipid-lowering effects.FITOTERAPIA,162,8.
MLA Tan, Yuqi,et al."Naphthoquinones and triterpenoids from Arnebia euchroma (Royle) Johnst and their hypoglycemic and lipid-lowering effects".FITOTERAPIA 162(2022):8.

入库方式： OAI收割

来源：上海药物研究所

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