New Rufomycins from Streptomyces atratus MJM3502 Expand Anti- Mycobacterium tuberculosis Structure-Activity Relationships
文献类型：期刊论文
| 作者 | Zhou, Bin2,3,4,5; Shetye, Gauri3; Wolf, Nina M.3; Chen, Shao-Nong3,4,5; Qader, Mallique3; Ray, G. Joseph3,4,5; Lankin, David C.3,4,5; Cho, Sanghyun3; Cheng, Jinhua1; Suh, Joo-Won1 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2022-10-04 |
| 页码 | 6 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.2c02493 |
| 通讯作者 | McAlpine, James B.(mcalpine@uic.edu) ; Pauli, Guido F.(gfp@uic.edu) |
| 英文摘要 | Four new rufomycins, compounds 1-4, named rufomycins 56, 57, 58, and 61, respectively, exhibiting new skeletal features, were obtained from Streptomyces atratus strain MJM3502 and were fully characterized. Compounds 1 and 2 possess a 4imidazolidinone ring not previously encountered in this family of cyclopeptides, thereby resulting in a [5,17] bicyclic framework. The in vitro anti -Mycobacterium tuberculosis potency of compounds 3 and 4 is remarkable, with minimum inhibitory concentration values of 8.5 and 130 nM, respectively. |
| WOS关键词 | ABSOLUTE-CONFIGURATION |
| 资助项目 | Centers of Excellence for Translational Research (CETR) Grant from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH)[U19AI142735] ; Cooperative Research Program for Agriculture Science and Technology Development[PJ01564001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000868931300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303256]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | McAlpine, James B.; Pauli, Guido F. |
| 作者单位 | 1.Myongji Univ, Myongji Bioefficacy Res Ctr, Yongin 17058, Gyeonggi Do, South Korea 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Illinois, Inst TB Res, Coll Pharm, Chicago, IL 60612 USA 4.Univ Illinois, Dept Pharmaceut Sci Coll Pharm, Chicago, IL 60612 USA 5.Univ Illinois, Pharmacognosy Inst, Coll Pharm, Chicago, IL 60612 USA |
| 推荐引用方式 GB/T 7714 | Zhou, Bin,Shetye, Gauri,Wolf, Nina M.,et al. New Rufomycins from Streptomyces atratus MJM3502 Expand Anti- Mycobacterium tuberculosis Structure-Activity Relationships[J]. ORGANIC LETTERS,2022:6. |
| APA | Zhou, Bin.,Shetye, Gauri.,Wolf, Nina M..,Chen, Shao-Nong.,Qader, Mallique.,...&Pauli, Guido F..(2022).New Rufomycins from Streptomyces atratus MJM3502 Expand Anti- Mycobacterium tuberculosis Structure-Activity Relationships.ORGANIC LETTERS,6. |
| MLA | Zhou, Bin,et al."New Rufomycins from Streptomyces atratus MJM3502 Expand Anti- Mycobacterium tuberculosis Structure-Activity Relationships".ORGANIC LETTERS (2022):6. |
入库方式： OAI收割
来源：上海药物研究所
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