Design of an activatable NIR-II nanoprobe for the in vivo elucidation of Alzheimer's disease-related variations in methylglyoxal concentrations
文献类型：期刊论文
| 作者 | Lai, Yi2; Dang, Yijing2; Sun, Qian2; Pan, Jiaxing1; Yu, Haijun1 ; Zhang, Wen2; Xu, Zhiai2
|
| 刊名 | CHEMICAL SCIENCE
 |
| 出版日期 | 2022-11-02 |
| 卷号 | 13期号:42页码:12511-12518 |
| ISSN号 | 2041-6520 |
| DOI | 10.1039/d2sc05242c |
| 通讯作者 | Zhang, Wen(wzhang@chem.ecnu.edu.cn) ; Xu, Zhiai(zaxu@chem.ecnu.edu.cn) |
| 英文摘要 | Clear elucidation of the changes in Alzheimer's disease (AD)-related methylglyoxal (MGO) levels in vivo is significant yet highly challenging. Fluorescence imaging in the second near-infrared region (NIR-II, 1000-1700 nm) has gained increasing attention as an observation method in living organisms, but an MGO-activatable fluorescent probe that emits in this region for in vivo brain imaging is lacking because of the existence of the blood-brain barrier (BBB). Herein, a biocompatible Fe3O4 nanoparticle (IONP)-conjugated MGO-activatable NIR-II fluorescent probe (MAM) modified with the peptide T7 (HAIYPRH) (named TM-IONP) is reported for the in situ detection of MGO in a transgenic AD mouse model. In this system, the T7 peptide enhances BBB crossing and brain accumulation by specifically targeting transferrin receptors on the BBB. Due to the MAM probe, TM-IONPs emit fluorescence in the NIR-II region and display high selectivity with an MGO detection limit of 72 nM and a 10-fold increase in the fluorescence signal. After intravenous administration, the TM-IONPs are easily delivered to the brain and pass through the BBB without intervention, and as a result, the brains of AD mice can be noninvasively imaged for the first time by the in situ detection of MGO with a 24.2-fold enhancement in NIR-II fluorescence intensity compared with wild-type mice. Thus, this MGO-activated NIR-II-emitting nanoprobe is potentially useful for early AD diagnosis in clinic. |
| WOS关键词 | INFRARED FLUORESCENT-PROBE ; TURN-ON ; LIGAND |
| 资助项目 | National Natural Science Foundation of China[22074043] ; National Natural Science Foundation of China[22174047] ; Science and Technology Commission of Shanghai Municipality[20142202800] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000869863200001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303262]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Wen; Xu, Zhiai |
| 作者单位 | 1.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 2.East China Normal Univ, Sch Chem & Mol Engn, 500 Dongchuan Rd, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lai, Yi,Dang, Yijing,Sun, Qian,et al. Design of an activatable NIR-II nanoprobe for the in vivo elucidation of Alzheimer's disease-related variations in methylglyoxal concentrations[J]. CHEMICAL SCIENCE,2022,13(42):12511-12518. |
| APA | Lai, Yi.,Dang, Yijing.,Sun, Qian.,Pan, Jiaxing.,Yu, Haijun.,...&Xu, Zhiai.(2022).Design of an activatable NIR-II nanoprobe for the in vivo elucidation of Alzheimer's disease-related variations in methylglyoxal concentrations.CHEMICAL SCIENCE,13(42),12511-12518. |
| MLA | Lai, Yi,et al."Design of an activatable NIR-II nanoprobe for the in vivo elucidation of Alzheimer's disease-related variations in methylglyoxal concentrations".CHEMICAL SCIENCE 13.42(2022):12511-12518. |
入库方式： OAI收割
来源：上海药物研究所
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