Potential adverse outcome pathways with hazard identification of organophosphate esters
文献类型：期刊论文
| 作者 | Wang, Xiaoqing2,4 ; Li, Fei1,3,4; Teng, Yuefa2,4; Ji, Chenglong3,4; Wu, Huifeng3,4
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2022-12-10 |
| 卷号 | 851页码:13 |
| 关键词 | Organophosphate esters (OPEs) Network-centric analysis Risk assessment Adverse outcome pathway Quantitative weight of evidence |
| ISSN号 | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2022.158093 |
| 通讯作者 | Li, Fei(fli@yic.ac.cn) |
| 英文摘要 | Data-driven analysis and pathway-based approaches contribute to reasonable arrangements of limited resources and laboratory tests for continuously emerging commercial chemicals, which provides opportunities to save time and effort for toxicity research. With the widespread usage of organophosphate esters (OPEs) on a global scale, the concentra-tions generally reached up to micromolar range in environmental media and even in organisms. However, potential adverse effects and toxicity pathways of OPEs have not been systematically assessed. Therefore, it is necessary to review the current situation, formulate the future research priorities, and characterize toxicity mechanisms via data -driven analysis. Results showed that the early toxicity studies focused on neurotoxicity, cytotoxicity, and metabolic disorders. Then the main focus shifted to the mechanisms of cardiotoxicity, endocrine disruption, hepatocytes, repro-ductive and developmental toxicity to vulnerable sub-populations, such as infants and embryos, affected by OPEs. In addition, several novel OPEs have been emerging, such as bis(2-ethylhexyl)-phenyl phosphate (HDEHP) and oxidation derivatives (OPAs=O) generated from organophosphite antioxidants (OPAs), leading to multiple potential ecological and human health risks (neurotoxicity, hepatotoxicity, developmental toxicity, etc.). Notably, in-depth statistical anal-ysis was promising in encapsulating toxicological information to develop adverse outcome pathways (AOPs) frame-works. Subsequently, network-centric analysis and quantitative weight-of-evidence (QWOE) approaches were utilized to construct and evaluate the putative AOPs frameworks of OPEs, showing the moderate confidences of the developed AOPs. In addition, frameworks demonstrated that several events, such as nuclear receptor activation, reac-tive oxygen species (ROS) production, oxidative stress, and DNA damage, were involved in multiple different adverse outcome (AO), and these AOs had certain degree of connectivity. This study brought new insights into facilitating the complement of AOP efficiently, as well as establishing toxicity pathways framework to inform risk assessment of emerging OPEs. |
| WOS关键词 | TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE TDCPP ; REGULATORY DECISION-MAKING ; FLAME RETARDANTS OPFRS ; EARLY-LIFE STAGES ; TRIPHENYL PHOSPHATE ; DEVELOPMENTAL NEUROTOXICITY ; ENDOCRINE DISRUPTION ; FIREMASTER(R) 550 ; OXIDATIVE STRESS ; TROPHIC TRANSFER |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:000877919900015 |
| 资助机构 | National Natural Science Foundation of China ; Yantai Science and Technology Development Plan ; Youth Innovation Promotion Association CAS |
| 源URL | [http://ir.yic.ac.cn/handle/133337/31990]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 烟台海岸带研究所_近岸生态与环境实验室 |
| 通讯作者 | Li, Fei |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCA, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaoqing,Li, Fei,Teng, Yuefa,et al. Potential adverse outcome pathways with hazard identification of organophosphate esters[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,851:13. |
| APA | Wang, Xiaoqing,Li, Fei,Teng, Yuefa,Ji, Chenglong,&Wu, Huifeng.(2022).Potential adverse outcome pathways with hazard identification of organophosphate esters.SCIENCE OF THE TOTAL ENVIRONMENT,851,13. |
| MLA | Wang, Xiaoqing,et al."Potential adverse outcome pathways with hazard identification of organophosphate esters".SCIENCE OF THE TOTAL ENVIRONMENT 851(2022):13. |
入库方式： OAI收割
来源：烟台海岸带研究所
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