Preparation, Anticoagulant and Antioxidant Properties of Glucosamine-Heparin Salt
文献类型：期刊论文
| 作者 | Miao, Qin1,2,3; Li, Qing2,3 ; Tan, Wenqiang2,3; Mi, Yingqi2,3; Ma, Bing1,2,3; Zhang, Jingjing2,3; Guo, Zhanyong2,3
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| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2022-10-01 |
| 卷号 | 20期号:10页码:13 |
| 关键词 | glucosamine-heparin salt glucosamine hydrochloride heparin sodium antioxidant activity anticoagulant activity |
| DOI | 10.3390/md20100646 |
| 英文摘要 | Excessive inorganic ions in vivo may lead to electrolyte disorders and induce damage to the human body. Therefore, preparation of enhanced bioactivity compounds, composed of activated organic cations and organic anions, is of great interest among researchers. In this work, glucosamine-heparin salt (GHS) was primarily synthesized with positively charged glucosamine hydrochloride (GAH) and negatively charged heparin sodium (Heps) by ion exchange method. Then, the detailed structural information of the GHS was characterized by FTIR, H-1 NMR spectroscopy and ICP-MS. In addition, its anticoagulant potency and antioxidant properties were evaluated, respectively. The results demonstrated that GHS salt achieved enhanced antioxidant activities, including 98.78% of O-2 center dot(-) radical scavenging activity, 91.23% of center dot OH radical scavenging rate and 66.49% of DPPH radical scavenging capacity at 1.6 mg/mL, severally. Meanwhile, anticoagulant potency (ATTP) of GHS strengthened from 153.10 +/- 17.14 to 180.03 +/- 6.02 at 0.75 mu mol/L. Thus, introducing cationic glucosamine residues into GHS could improve its anticoagulant activity. The findings suggest that GHS product with a small amount of inorganic ions can greatly abate the prime cost of antioxidants and anticoagulants, and has significant economic benefits and practical significance. |
| WOS关键词 | MOLECULAR-MECHANISMS ; CHROMATOGRAPHY |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000873168100001 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/31948]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Guo, Zhanyong |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Miao, Qin,Li, Qing,Tan, Wenqiang,et al. Preparation, Anticoagulant and Antioxidant Properties of Glucosamine-Heparin Salt[J]. MARINE DRUGS,2022,20(10):13. |
| APA | Miao, Qin.,Li, Qing.,Tan, Wenqiang.,Mi, Yingqi.,Ma, Bing.,...&Guo, Zhanyong.(2022).Preparation, Anticoagulant and Antioxidant Properties of Glucosamine-Heparin Salt.MARINE DRUGS,20(10),13. |
| MLA | Miao, Qin,et al."Preparation, Anticoagulant and Antioxidant Properties of Glucosamine-Heparin Salt".MARINE DRUGS 20.10(2022):13. |
入库方式： OAI收割
来源：烟台海岸带研究所
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