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Synthesis of Water-Soluble Sulfonated Chitin Derivatives for Potential Antioxidant and Antifungal Activity

文献类型：期刊论文

作者Luan, Fang3; Xu, Zhenhua3; Wang, Kai3; Qi, Xin3; Guo, Zhanyong1,2
刊名MARINE DRUGS
出版日期2022-11-01
卷号20期号:11页码:14
关键词water-soluble chitin derivative sulfonated chitin antioxidant ability antifungal activity
DOI10.3390/md20110668
通讯作者Luan, Fang(221010@sdjtu.edu.cn) ; Guo, Zhanyong(zyguo@yic.ac.cn)
英文摘要Chitin is a natural renewable and useful biopolymer limited by its insolubility; chemical derivatization can enhance the solubility and bioactivity of chitin. The purpose of this study was to synthesize novel water-soluble chitin derivatives, sulfo-chitin (SCT) and sulfopropyl-chitin (SPCT), as antioxidant and antifungal agents. The target derivatives were characterized by means of elemental analysis, FTIR, C-13 NMR, TGA and XRD. Furthermore, the antioxidant activity of the chitin derivatives was estimated by free radical scavenging ability (against DPPH-radical, hydroxyl-radical and superoxide-radical) and ferric reducing power. In addition, inhibitory effects against four fungi were also tested. The findings show that antioxidant abilities and antifungal properties were in order of SPCT > SCT > CT. On the basis of the results obtained, we confirmed that the introduction of sulfonated groups on the CT backbone would help improve the antioxidant and antifungal activity of CT. Moreover, its efficacy as an antioxidant and antifungal agent increased as the chain length of the substituents increased. This derivatization strategy might provide a feasible way to broaden the utilization of chitin. It is of great significance to minimize waste and realize the high-value utilization of aquatic product wastes.
WOS关键词CARBOXYMETHYL CHITOSAN ; NANOPARTICLES ; EXTRACTION ; DELIVERY ; OXIDE
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000881069500001
资助机构Natural Science Foundation of Shandong Province of China
源URL[http://ir.yic.ac.cn/handle/133337/31999]  
专题海岸带生物学与生物资源利用重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
通讯作者Luan, Fang; Guo, Zhanyong
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
3.Shandong Jiaotong Univ, Naval Architecture & Port Engn Coll, Weihai 264200, Peoples R China
推荐引用方式
GB/T 7714		 Luan, Fang,Xu, Zhenhua,Wang, Kai,et al. Synthesis of Water-Soluble Sulfonated Chitin Derivatives for Potential Antioxidant and Antifungal Activity[J]. MARINE DRUGS,2022,20(11):14.
APA Luan, Fang,Xu, Zhenhua,Wang, Kai,Qi, Xin,&Guo, Zhanyong.(2022).Synthesis of Water-Soluble Sulfonated Chitin Derivatives for Potential Antioxidant and Antifungal Activity.MARINE DRUGS,20(11),14.
MLA Luan, Fang,et al."Synthesis of Water-Soluble Sulfonated Chitin Derivatives for Potential Antioxidant and Antifungal Activity".MARINE DRUGS 20.11(2022):14.

入库方式： OAI收割

来源：烟台海岸带研究所

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