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Unravelling the characterization of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and antioxidant enzymes in clam Cyclina sinensis in response to hypoxia

文献类型：期刊论文

作者Ni, Qian4; Wang, Di4; Xie, Lingli4; Ge, Hongxing2,3,4; Dong, Zhiguo1,3,4
刊名AQUACULTURE RESEARCH
出版日期2022-09-01
页码9
ISSN号1355-557X
关键词antioxidant enzymes clone Cyclina sinensis HIF-1 alpha hypoxia
DOI10.1111/are.16062
通讯作者Ge, Hongxing(hongxinggeliu@163.com) ; Dong, Zhiguo(dzg2004@163.com)
英文摘要Aquatic hypoxia has negative or detrimental effects on clams. To cope with hypoxia stress, a complex series of physiological and biochemical strategies can be employed in clams. Hypoxia-inducible factor-1 alpha (HIF-1 alpha) and antioxidant enzymes are commonly found in aquatic animals as an adaptation against hypoxia. In the present study, we cloned the HIF-1 alpha sequence in clam Cyclina sinensis, and it consists of 2654 base pairs (bp) carrying a single open-reading frame that encompasses 2235 bp of the coding region. The predicted C. sinensis HIF-1 alpha protein (744 amino acids) has the conserved HLH-PAS domain, which contained one N-terminal basic helix-loop-helix (bHLH) domain and two Per-ARNT-Sim A/B (PAS) domains, followed by PAS-associated C-terminal (PAC) domain. HIF-1 alpha is expressed predominantly in gills. Exposed to hypoxia, the transcript level of HIF-1 alpha was significantly up-regulated in response to hypoxia, and then, the transcript level declined continuously with the time elapsed. The antioxidant enzymes (SOD, CAT and GSH-PX) in gills were increased initially and then decreased after acute hypoxia exposure. Our study indicates that the HIF-1 alpha gene and antioxidant enzymes may play an important role in cope with acute hypoxia exposure.
资助项目National key research and development projects[2020YFD0900203-02]
WOS研究方向Fisheries
语种英语
出版者WILEY
WOS记录号WOS:000848478300001
源URL[http://ir.qdio.ac.cn/handle/337002/180906]  
专题中国科学院海洋研究所
通讯作者Ge, Hongxing; Dong, Zhiguo
作者单位1.Jiangsu Ocean Univ, Jiangsu Key Lab Marine Biotechnol, Lianyungang, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
3.Jiangsu Inst Marine Resources Dev, Lianyungang, Peoples R China
4.Jiangsu Ocean Univ, Jiangsu Key Lab Marine Bioresources & Environm, Lianyungang 222005, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Ni, Qian,Wang, Di,Xie, Lingli,et al. Unravelling the characterization of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and antioxidant enzymes in clam Cyclina sinensis in response to hypoxia[J]. AQUACULTURE RESEARCH,2022:9.
APA Ni, Qian,Wang, Di,Xie, Lingli,Ge, Hongxing,&Dong, Zhiguo.(2022).Unravelling the characterization of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and antioxidant enzymes in clam Cyclina sinensis in response to hypoxia.AQUACULTURE RESEARCH,9.
MLA Ni, Qian,et al."Unravelling the characterization of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and antioxidant enzymes in clam Cyclina sinensis in response to hypoxia".AQUACULTURE RESEARCH (2022):9.

入库方式： OAI收割

来源：海洋研究所

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