Theoretical analysis of RNA polymerase fidelity: a steady-state copolymerization approach
文献类型：期刊论文
| 作者 | Fu, Wenbo; Li, Qiushi; Song, Yongshun4; Shu, Yaogen1; Ouyang, Zhongcan2 ; Li, Ming
|
| 刊名 | COMMUNICATIONS IN THEORETICAL PHYSICS
 |
| 出版日期 | 2022 |
| 卷号 | 74期号:1页码:15601 |
| 关键词 | MECHANISM TRANSCRIPT ACCURACY CLEAVAGE ERRORS |
| ISSN号 | 0253-6102 |
| DOI | 10.1088/1572-9494/ac3993 |
| 英文摘要 | The fidelity of DNA transcription catalyzed by RNA polymerase (RNAP) has long been an important issue in biology. Experiments have revealed that RNAP can incorporate matched nucleotides selectively and proofread the incorporated mismatched nucleotides. However, systematic theoretical researches on RNAP fidelity are still lacking. In the last decade, several theories on RNA transcription have been proposed, but they only handled highly simplified models without considering the high-order neighbor effects and the oligonucleotides cleavage both of which are critical for the overall fidelity. In this paper, we regard RNA transcription as a binary copolymerization process and calculate the transcription fidelity by the steady-state copolymerization theory recently proposed by us for DNA replication. With this theory, the more realistic models considering higher-order neighbor effects, oligonucleotides cleavage, multi-step incorporation and multi-step cleavage can be rigorously handled. |
| 学科主题 | Physics |
| 语种 | 英语 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/27892]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 作者单位 | 1.East China Univ Sci & Technol, Sch Phys, Shanghai 200237, Peoples R China 2.Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Peoples R China 3.Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Wenbo,Li, Qiushi,Song, Yongshun,et al. Theoretical analysis of RNA polymerase fidelity: a steady-state copolymerization approach[J]. COMMUNICATIONS IN THEORETICAL PHYSICS,2022,74(1):15601. |
| APA | Fu, Wenbo,Li, Qiushi,Song, Yongshun,Shu, Yaogen,Ouyang, Zhongcan,&Li, Ming.(2022).Theoretical analysis of RNA polymerase fidelity: a steady-state copolymerization approach.COMMUNICATIONS IN THEORETICAL PHYSICS,74(1),15601. |
| MLA | Fu, Wenbo,et al."Theoretical analysis of RNA polymerase fidelity: a steady-state copolymerization approach".COMMUNICATIONS IN THEORETICAL PHYSICS 74.1(2022):15601. |
入库方式： OAI收割
来源：理论物理研究所
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