The potential diagnostic accuracy of urine formaldehyde levels in Alzheimer's disease: A systematic review and meta-analysis
文献类型：期刊论文
| 作者 | Chen, Fan3; Wang, Na3; Tian, Xinyan3; Qin, Yan3; Su, Juan3; He, Rongqiao1,2; He, Xiaping3 |
| 刊名 | FRONTIERS IN AGING NEUROSCIENCE
 |
| 出版日期 | 2022-12-13 |
| 卷号 | 14页码:13 |
| ISSN号 | 1663-4365 |
| 关键词 | Alzheimer's disease meta-analysis formaldehyde biomarkers diagnosis |
| DOI | 10.3389/fnagi.2022.1057059 |
| 通讯作者 | Su, Juan(sujuan@dali.edu.cn) ; He, Rongqiao(rongqiaohe@163.com) ; He, Xiaping(hxp@dali.edu.cn) |
| 英文摘要 | BackgroundFormaldehyde (FA), a toxic aldehyde, has been shown to be associated with a variety of cognitive disorders, including Alzheimer's disease (AD). There is increasing evidence that FA levels are significantly increased in AD patients and may be involved in the pathological process of AD. The aim of this study was to assess the potential diagnostic value of urine FA levels in AD using meta-analysis techniques. MethodsOriginal reports of morning urine FA levels in AD patients and healthy controls (HCs) were included in the meta-analysis. Standardized mean differences (SMD) were calculated using a random-effects model, heterogeneity was explored using methodological, age, sex difference and sensitivity analyses, and receiver operating characteristic (ROC) curves were constructed to assess the diagnostic value of urine FA levels in AD. ResultsA total of 12 studies were included, and the urine FA levels of 874 AD patients and 577 HCs were reviewed. Compared with those in HCs, the FA levels were significantly increased in AD patients. The heterogeneity of the results did not affect their robustness, and results of the area under the curve (AUC) suggested that urine FA levels had good potential diagnostic value. ConclusionUrine FA levels are involved in AD disease progression and are likely to be useful as a potential biomarker for clinical auxiliary diagnosis. However, further studies are needed to validate the results of this study. |
| 收录类别 | SCI |
| WOS关键词 | CEREBROSPINAL-FLUID ; AMYLOID-BETA ; MEMORY ; HYPERPHOSPHORYLATION ; PROTEIN |
| 资助项目 | High-Level Talent Research Start-up Fund Project of Dali University ; Joint Project of Local Universities of Yunnan Provincial Department of Science and Technology ; [KY1916103740] ; [202101BA070001-106] |
| WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000902451800001 |
| 资助机构 | High-Level Talent Research Start-up Fund Project of Dali University ; Joint Project of Local Universities of Yunnan Provincial Department of Science and Technology |
| 源URL | [http://ir.psych.ac.cn/handle/311026/44349]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Su, Juan; He, Rongqiao; He, Xiaping |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China 3.Dali Univ, Sch Basic Med Sci, Dali, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Fan,Wang, Na,Tian, Xinyan,et al. The potential diagnostic accuracy of urine formaldehyde levels in Alzheimer's disease: A systematic review and meta-analysis[J]. FRONTIERS IN AGING NEUROSCIENCE,2022,14:13. |
| APA | Chen, Fan.,Wang, Na.,Tian, Xinyan.,Qin, Yan.,Su, Juan.,...&He, Xiaping.(2022).The potential diagnostic accuracy of urine formaldehyde levels in Alzheimer's disease: A systematic review and meta-analysis.FRONTIERS IN AGING NEUROSCIENCE,14,13. |
| MLA | Chen, Fan,et al."The potential diagnostic accuracy of urine formaldehyde levels in Alzheimer's disease: A systematic review and meta-analysis".FRONTIERS IN AGING NEUROSCIENCE 14(2022):13. |
入库方式： OAI收割
来源：心理研究所
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