学龄期胼胝体形态发育研究
文献类型：学位论文
| 作者 | 曹立智
|
| 答辩日期 | 2022-12 |
| 文献子类 | 博士 |
| 授予单位 | 中国科学院大学 |
| 授予地点 | 中国科学院心理研究所 |
| 其他责任者 | 左西年 |
| 关键词 | 胼胝体 信度 发育 认知 |
| 学位名称 | 理学博士 |
| 其他题名 | The morphological development of corpus callosum in school age children |
| 中文摘要 | The corpus callosum, the largest fiber tract connecting the cerebral hemispheres, is the principal path transferring information between hemispheres. The typical development of the corpus callosum is significant for the development of cognitive function, and agenesis of the corpus callosum, characterized by developmental absence of the corpus callosum is closely related to neurological and psychotic disorders. For the reason that school age is a neurobiological critical period for the development of brain and cognitive function, this present study explored the typical growing law of corpus callosum morphology during school age in China and the relationship between the development of corpus callosum morphology and the development of cognitive function. Three studys had been included in this project. Study 1 examined the reliability of corpus callosum morphology measurement, which was precondition for scientific research involving corpus callosum morphology. In study 2, the development trajectories of multiple corpus callosum morphology measurement indexes during school age were built in China. In study 3, the relationships between the development of cognitive function and the development of corpus callosum morphology in school age were investigated. In the first study, for examining the test-retest reliability of corpus callosum morphology measuring, fifty-four adults (18 ~ 36 years old) from the 3R-Brain Project were scanned four times in two different 3T magnetic resonance scaners from two different sites. The results showed that for most of corpus callosum morphology measurement indexes, the test-retest reliability was almost perfect (ICC > 0.8). However, for the thickness of the two ends of the corpus callosum, the test-retest reliability was lower. The test-retest reliability intra-scaner is heigher than the test-retest reliability inter-scaners. In the second study, based on the accelerated longitudinal design, 391 Chinese children in school-age (6 ~ 18 years old) were traced. The Generalized Additive Mixed Models (GAMM) was applying to draw the developmental trajectories of corpus callosum morphology. The results showed that the development of corpus callosum morphology was dynamic in school-age children. Pubertal development of the corpus callosum was again accelerated. The boys’ developmental trajectories of corpus callosum morphology were different than girls’. After 16 years old, the corpus callosum area begins to decline in girls. The developmental trajectories of different corpus callosum regions were different from each other. The development rate of the genu and splenium of the corpus callosum decreased with age. However, the development rate of the middle region is relatively stable. Introducing the total intracranial volume (eTIV) as additional covariate, the developmental trajectories of corpus callosum morphology were still significant. The developmental trajectories of relative measuring of corpus callosum morphology were significant, which meant the development of corpus callosum was over-proportional. In study 3, the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) was used to assess children’s cognitive functions. The GAMM was applying to exploring the relationships between corpus callosum morphology and cognitive functions. The time-varying effect model was applying to exploring whether the relationships between corpus callosum morphology and cognitive functions varied with age. The results showed that the development of corpus callosum morphology could explain the development of cognitive functions. And the relationships were moderated by sex and corpus callosum region. The relationships between corpus callosum morphology and cognitive functions varied with age. |
| 英文摘要 | 胼胝体是连接两侧大脑半球的最大连合纤维，是大脑两半球间传递和协调信息的主要途径。胼胝体的正常发育是认知功能正常发展的基础，胼胝体的发育异常与认知障碍以及神经精神疾病密切相关。学龄期是大脑发育以及认知发展的关键期，因此本研究探索了中国学龄期儿童胼胝体形态的典型发育规律以及胼胝体发育与认知发展的关系。本研究包括三个子研究：研究一考察了胼胝体形态学测量的重测信度，为涉及胼胝体形态的研究提供信度支持；研究二构建了中国学龄期儿童胼胝体形态学测量多指标的随龄发育轨线；研究三探索了学龄期儿童胼胝体形态发育与认知发展的关系。 研究一基于多模态磁共振成像重测数据集“3R_BRAIN”，考察了胼胝体形态测量的重测信度。54 个 18 ~ 36 岁的健康成年人在两台 3T 磁共振扫描仪上完成了四次扫描。结果表明，对于大部分的胼胝体形态测量，具有近乎完美（ICC > 0.8）的重测信度，胼胝体两端厚度的重测信度要相对低一些。站点内的重测信度高于站点间的重测信度。 研究二采用纵向加速设计，对 6 ~ 18 岁健康的中国学龄期儿童进行追踪测量。采用广义可加混合模型构建胼胝体形态发育轨线。结果表明，学龄期胼胝体形态的发育是一个动态变化的过程，青春期胼胝体发育再次进入加速期。学龄期胼胝体形态发育存在区域差异，胼胝体膝部和胼胝体压部发育速度随龄下降，而胼胝体中间区域发育速度相对平稳。学龄期胼胝体形态发育存在性别差异，16 岁之后女性胼胝体面积开始下降。考虑颅内体积影响情况下胼胝体形态依然显著随龄变化。胼胝体形态相对测量（胼胝体形态测量与颅内体积的比率）随龄显著变化，表明胼胝体是超比例发育的。 研究三使用韦氏儿童智力量表第四版（中文版）对认知功能进行测试。采用广义可加混合模型探索学龄期发育中的胼胝体形态与发育中的认知功能的关系。采用时变效应模型考察学龄期胼胝体形态与认知功能的关系是否随着年龄变化。结果表明，学龄期胼胝体形态的发育与认知功能的发展有关。胼胝体形态与认知功能的关联存在性别差异。学龄期胼胝体形态与认知功能的关联存在区域差。 |
| 语种 | 中文 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/44372]  |
| 专题 | 心理研究所_认知与发展心理学研究室 |
| 推荐引用方式 GB/T 7714 | 曹立智. 学龄期胼胝体形态发育研究[D]. 中国科学院心理研究所. 中国科学院大学. 2022. |
入库方式： OAI收割
来源：心理研究所
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