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Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes

文献类型：期刊论文

作者Chen, Shenbao4,5; Zhu, Jingchen4,5; Xue, Jian3,4; Wang, Xiaolong2; Jing, Peng2; Zhou, Luwen4,5; Cui, Yuhong1; Wang, Tianhao1; Gong, Xiaobo2; Lu, Shouqin4,5
刊名BIOPHYSICAL JOURNAL
出版日期2022-12-06
卷号121期号:23页码:4666-4678
ISSN号0006-3495
DOI10.1016/j.bpj.2022.10.022
通讯作者Gong, Xiaobo(x.gong@sjtu.edu.cn) ; Lu, Shouqin(lsq@imech.ac.cn) ; Long, Mian(mlong@imech.ac.cn)
英文摘要Double-layered channels of sinusoid lumen and Disse space separated by fenestrated liver sinusoidal endothelial cells (LSECs) endow the unique mechanical environment of the liver sinusoid network, which further guarantees its biological function. It is also known that this mechanical environment changes dramatically under liver fibrosis and cirrhosis, including the reduced plasma penetration and metabolite exchange between the two flow channels and the reduced Disse space deformabil-ity. The squeezing of leukocytes through narrow sinusoid lumen also affects the mechanical environment of liver sinusoid. To date, the detailed flow-field profile of liver sinusoid is still far from clear due to experimental limitations. It also remains elusive whether and how the varied physical properties of the pathological liver sinusoid regulate the fluid flow characteristics. Here a numerical model based on the immersed boundary method was established, and the effects of Disse space and leukocyte elas-ticities, endothelium permeability, and sinusoidal stenosis degree on fluid flow as well as leukocyte trafficking were specified upon a mimic liver sinusoid structure. Results showed that endothelium permeability dominantly controlled the plasma penetra-tion velocity across the endothelium, whereas leukocyte squeezing promoted local penetration and significantly regulated wall shear stress on hepatocytes, which was strongly related to the Disse space and leukocyte deformability. Permeability and elas-ticity cooperatively regulated the process of leukocytes trafficking through the liver sinusoid, especially for stiffer leukocytes. This study will offer new insights into deeper understanding of the elaborate mechanical features of liver sinusoid and corresponding biological function.
WOS关键词BLOOD-FLOW ; HEPATOCYTE FUNCTION ; CELLS ; NEUTROPHILS ; MODEL
资助项目National Natural Science Foundation of China ; Scientific Instrument Developing Project of Chinese Academy of Sciences ; [32130061] ; [11972042] ; [12072198] ; [GJJSTU20190005]
WOS研究方向Biophysics
语种英语
WOS记录号WOS:000901491100002
资助机构National Natural Science Foundation of China ; Scientific Instrument Developing Project of Chinese Academy of Sciences
源URL[http://dspace.imech.ac.cn/handle/311007/91386]  
专题力学研究所_国家微重力实验室
力学研究所_非线性力学国家重点实验室
通讯作者Gong, Xiaobo; Lu, Shouqin; Long, Mian
作者单位1.Tianjin Univ, Dept Mech, Tianjin, Peoples R China
2.Shanghai Jiao Tong Univ, Shanghai, Peoples R China
3.Inst Mech, Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, CAS Ctr Excellence Complex Syst Mech, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Shenbao,Zhu, Jingchen,Xue, Jian,et al. Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes[J]. BIOPHYSICAL JOURNAL,2022,121(23):4666-4678.
APA Chen, Shenbao.,Zhu, Jingchen.,Xue, Jian.,Wang, Xiaolong.,Jing, Peng.,...&Chen SB.(2022).Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes.BIOPHYSICAL JOURNAL,121(23),4666-4678.
MLA Chen, Shenbao,et al."Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes".BIOPHYSICAL JOURNAL 121.23(2022):4666-4678.

入库方式： OAI收割

来源：力学研究所

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