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New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination

文献类型：期刊论文

作者Chen, He5; Wang, Menghan4; Xia, Lin2,3; Dong, Jiong1,3; Xu, Guangwei5; Wang, Ziyi5; Feng, Lixia2,3; Zhou, Yifeng1,5
刊名DIABETES
出版日期2022-08-01
卷号71期号:8页码:1772-1784
ISSN号0012-1797
DOI10.2337/db21-0715
通讯作者Feng, Lixia(lixiafeng@163.com) ; Zhou, Yifeng(zhouy@ustc.edu.cn)
英文摘要Diabetes can damage both the peripheral sensory organs, causing retinopathy, and the central visual system, leading to contrast sensitivity and impaired color vision in patients without retinopathy. Orientation discrimination is important for shape recognition by the visual system. Our psychophysical findings in this study show diminished orientation discrimination in patients with diabetes without retinopathy. To reveal the underlying mechanism, we established a diabetic mouse model and recorded in vivo electrophysiological data in the dorsal lateral geniculate nucleus (dLGN) and primary visual cortex (V1). Reduced orientation selectivity was observed in both individual and populations of neurons in V1 and dLGN, which increased in severity with disease duration. This diabetes-associated neuronal dysfunction appeared earlier in the V1 than dLGN. Additionally, neuronal activity and signal-to-noise ratio are reduced in V1 neurons of diabetic mice, leading to a decreased capacity for information processing by V1 neurons. Notably, the V1 in diabetic mice exhibits reduced excitatory neuronal activity and lower levels of phosphorylated mammalian target of rapamycin (mTOR). Our findings show that altered responses of both populations of and single V1 neurons may impair fine vision, thus expanding our understanding of the underlying causes of diabetes-related impairment of the central nervous system.
收录类别SCI
WOS关键词ORIENTATION SELECTIVITY ; RECEPTIVE FIELDS ; NEURONS ; CORTEX ; BRAIN ; AFFERENTS ; GABA
资助项目National Natural Science Foundation of China[NSFC 32070990] ; Anhui Province's Key Research and Development Plan[9021033204]
WOS研究方向Endocrinology & Metabolism
语种英语
出版者AMER DIABETES ASSOC
WOS记录号WOS:000905184100019
资助机构National Natural Science Foundation of China ; Anhui Province's Key Research and Development Plan
源URL[http://ir.psych.ac.cn/handle/311026/44415]  
专题心理研究所_认知与发展心理学研究室
通讯作者Feng, Lixia; Zhou, Yifeng
作者单位1.Chinese Acad Sci, Inst Psychol, State Key Lab Brain & Cognit Sci, Hefei, Peoples R China
2.Natl Clin Res Ctr Ocular Dis, Anhui Branch, Hefei, Peoples R China
3.Anhui Med Univ, Dept Ophthalmol, Affiliated Hosp 1, Hefei, Peoples R China
4.Univ Sci & Technol China, Sch Informat Sci & Technol, Hefei, Peoples R China
5.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Sch Life Sci, Hefei, Peoples R China
推荐引用方式
GB/T 7714		 Chen, He,Wang, Menghan,Xia, Lin,et al. New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination[J]. DIABETES,2022,71(8):1772-1784.
APA Chen, He.,Wang, Menghan.,Xia, Lin.,Dong, Jiong.,Xu, Guangwei.,...&Zhou, Yifeng.(2022).New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination.DIABETES,71(8),1772-1784.
MLA Chen, He,et al."New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination".DIABETES 71.8(2022):1772-1784.

入库方式： OAI收割

来源：心理研究所

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