Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty
文献类型：期刊论文
| 作者 | Hu, Xiaonan1; Meng, Zhen2 |
| 刊名 | ANNALS OF HUMAN GENETICS
 |
| 出版日期 | 2022-05-18 |
| 页码 | 11 |
| 关键词 | gene-environment interaction gene-gene interaction genetic model potential variable power |
| ISSN号 | 0003-4800 |
| DOI | 10.1111/ahg.12470 |
| 英文摘要 | One of the critical issues in genetic association studies is to evaluate the risk of a disease associated with gene-gene or gene-environment interactions. The commonly employed procedures are derived by assigning a particular set of scores to genotypes. However, the underlying genetic models of inheritance are rarely known in practice. Misspecifying a genetic model may result in power loss. By using some potential genetic variables to separate the genotype coding and genetic model parameter, we construct a model-embedded score test (MEST). Our test is free of assumption of gene-environment independence and allows for covariates in the model. An effective sequential optimization algorithm is developed. Extensive simulations show the proposed MEST is robust and powerful in most of scenarios. Finally, we apply the proposed method to rheumatoid arthritis data from the Genetic Analysis Workshop 16 to further investigate the potential interaction effects. |
| 资助项目 | Capital University of Economics and Business Newly Recruited Young Teachers Scientific Research Start-up Foundation Project[XRZ2022066] |
| WOS研究方向 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000796863600001 |
| 出版者 | WILEY |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/61318]  |
| 专题 | 中国科学院数学与系统科学研究院 |
| 通讯作者 | Meng, Zhen |
| 作者单位 | 1.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, Beijing, Peoples R China 2.Capital Univ Econ & Business, Sch Stat, Xincun St, Beijing 100070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xiaonan,Meng, Zhen. Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty[J]. ANNALS OF HUMAN GENETICS,2022:11. |
| APA | Hu, Xiaonan,&Meng, Zhen.(2022).Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty.ANNALS OF HUMAN GENETICS,11. |
| MLA | Hu, Xiaonan,et al."Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty".ANNALS OF HUMAN GENETICS (2022):11. |
入库方式： OAI收割
来源：数学与系统科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。