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Association of long-term air pollution exposure with the risk of prediabetes and diabetes: Systematic perspective from inflammatory mechanisms, glucose homeostasis pathway to preventive strategies

文献类型：期刊论文

作者Mei, Yayuan4,5; Li, Ang4,5; Zhao, Jiaxin4,5; Zhou, Quan4,5; Zhao, Meiduo4,5; Xu, Jing4,5; Li, Runkui2,3; Li, Yanbing4,5; Li, Kai4,5; Ge, Xiaoyu4,5
刊名ENVIRONMENTAL RESEARCH
出版日期2023
卷号216页码:14
关键词Air pollutant Glucose homeostasis markers Mixture effect Mediation analysis Prediabetes
ISSN号0013-9351
DOI10.1016/j.envres.2022.114472
通讯作者Wei, Yongjie(weiyj@craes.org.cn) ; Xu, Qun(xuqun@ibms.cams.cn)
英文摘要Background:Limited evidence suggests the association of air pollutants with a series of diabetic cascades including inflammatory pathways, glucose homeostasis disorder, and prediabetes and diabetes. Subclinical strategies for preventing such pollutants-induced effects remain unknown. Methods:We conducted a cross-sectional study in two typically air-polluted Chinese cities in 2018-2020. One-year average PM1, PM2.5, PM10, SO2, NO2, and O-3 were calculated according to participants' residence. GAM multinomial logistic regression was performed to investigate the association of air pollutants with diabetes status. GAM and quantile g-computation were respectively performed to investigate individual and joint effects of air pollutants on glucose homeostasis markers (glucose, insulin, HbA1c, HOMA-IR, HOMA-B and HOMA-S). Complement C3 and hsCRP were analyzed as potential mediators. The ABCS criteria and hemoglobin glycation index (HGI) were examined for their potential in preventive strategy. Results:Long-term air pollutants exposure was associated with the risk of prediabetes [Prevalence ratio for O-3 (PR_O-3) = 1.96 (95% CI: 1.24, 3.03)] and diabetes [PR_PM1 = 1.18 (95% CI: 1.05, 1.32); PR_PM2.5 = 1.08 (95% CI: 1.00, 1.16); PR_O-3 = 1.35 (95% CI: 1.03, 1.74)]. PM1, PM10, SO2 or O-3 exposure was associated with glucose -homeostasis disorder. For example, O-3 exposure was associated with increased levels of glucose [7.67% (95% CI: 1.75, 13.92)], insulin [19.98% (95% CI: 4.53, 37.72)], HOMA-IR [34.88% (95% CI: 13.81, 59.84)], and decreased levels of HOMA-S [-25.88% (95% CI:-37.46,-12.16)]. Complement C3 and hsCRP played mediating roles in these relationships with proportion mediated ranging from 6.95% to 60.64%. Participants with HGI <=-0.53 were protected from the adverse effects of air pollutants. Conclusion:Our study provides comprehensive insights into air pollutant-associated diabetic cascade and suggests subclinical preventive strategies.
WOS关键词FASTING BLOOD-GLUCOSE ; BETA-CELL FUNCTION ; CONTROL ACTION PLAN ; C-REACTIVE PROTEIN ; INSULIN-RESISTANCE ; GLYCOSYLATED HEMOGLOBIN ; MODEL ASSESSMENT ; CHINA ; DYSFUNCTION ; MELLITUS
资助项目Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[2022-JKCS-11] ; CAMS Innovation Fund for Medical Sciences[2022-I2M-JB-003] ; Fundamental Research Funds for the Central Universities[2019-1004-02] ; Peking Union Medical College Graduate Innovation Fund[15-230] ; China Medical Board[2017-I2M-1-009] ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences[MEE-EH-20190802] ; China Prospective cohort study of Air pollution and halth effects in Typical areas (C-PAT) ; [3332019147]
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
语种英语
WOS记录号WOS:000901262000001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
资助机构Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences ; CAMS Innovation Fund for Medical Sciences ; Fundamental Research Funds for the Central Universities ; Peking Union Medical College Graduate Innovation Fund ; China Medical Board ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences ; China Prospective cohort study of Air pollution and halth effects in Typical areas (C-PAT)
源URL[http://ir.igsnrr.ac.cn/handle/311030/188917]  
专题中国科学院地理科学与资源研究所
通讯作者Wei, Yongjie; Xu, Qun
作者单位1.Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China
2.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing 100005, Peoples R China
5.Chinese Acad Med Sci, Peking Union Med Coll, Dept Epidemiol & Biostat, Inst Basic Med Sci,Sch Basic Med, Beijing 100005, Peoples R China
推荐引用方式
GB/T 7714		 Mei, Yayuan,Li, Ang,Zhao, Jiaxin,et al. Association of long-term air pollution exposure with the risk of prediabetes and diabetes: Systematic perspective from inflammatory mechanisms, glucose homeostasis pathway to preventive strategies[J]. ENVIRONMENTAL RESEARCH,2023,216:14.
APA Mei, Yayuan.,Li, Ang.,Zhao, Jiaxin.,Zhou, Quan.,Zhao, Meiduo.,...&Xu, Qun.(2023).Association of long-term air pollution exposure with the risk of prediabetes and diabetes: Systematic perspective from inflammatory mechanisms, glucose homeostasis pathway to preventive strategies.ENVIRONMENTAL RESEARCH,216,14.
MLA Mei, Yayuan,et al."Association of long-term air pollution exposure with the risk of prediabetes and diabetes: Systematic perspective from inflammatory mechanisms, glucose homeostasis pathway to preventive strategies".ENVIRONMENTAL RESEARCH 216(2023):14.

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来源：地理科学与资源研究所

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