P50 inhibition defects, psychopathology and gray matter volume in patients with first-episode drug-naive schizophrenia
文献类型:期刊论文
作者 | Lang, XiaoE2,6; Wang, Dongmei4,5; Zhou, Huixia4,5; Wang, Li; Kosten, Thomas R.3; Zhang, Xiang-Yang1,4,5 |
刊名 | ASIAN JOURNAL OF PSYCHIATRY |
出版日期 | 2023-02-01 |
卷号 | 80页码:8 |
通讯作者邮箱 | langxiaoe@yeah.net (x. lang) ; zhangxy@psych.ac.cn (x.-y. zhang) |
ISSN号 | 1876-2018 |
关键词 | Schizophrenia Gray matter volume Sensory gating P50 Symptom |
DOI | 10.1016/j.ajp.2022.103421 |
产权排序 | 2 |
文献子类 | 实证研究 |
英文摘要 | Background: Sensory gating deficits and gray matter volume (GMV) abnormalities have been found to be asso-ciated with the pathogenesis and psychopathology of patients with schizophrenia (SCZ). However, no studies have investigated their interrelationship in first-episode treatment-naive (FETN) SCZ patients.Methods: We recruited 52 FETN SCZ patients and 57 healthy controls. The Positive and Negative Syndrome Scale (PANSS) was used to measure the psychopathology of the patients. We collected magnetic resonance imaging and P50 inhibition data from all participants. Results: Compared to healthy controls, patients had shorter S1 and S2 latencies but larger S2 amplitudes and P50 ratio (Bonferroni adjusted all p < 0.01). In patients, S2 latency was independently associated with PANSS total score, negative symptoms and general psychopathology (t = 2.26-2.58, both P < 0.05), whereas S1 (t = 2.44, P < 0.05) and S2 latencies (t = 2.13, P < 0.05) were associated with PANSS cognitive factor. Moreover, GMV in the left inferior temporal gyrus, left lingual gyrus and right superior occipital gyrus, and bilateral dorsolateral su-perior frontal gyrus were each associated with the P50 components (all p < 0.05). In addition, GMV associated with S2 latency was negatively correlated with PANSS general psychopathology (t =-2.46, p < 0.05) and total score (t =-2.34, p < 0.05). Conclusions: Our findings indicate that FETN SCZ patients exhibit deficits in P50 inhibition and GMV of brain regions associated with these deficits may be associated with their psychopathological symptoms, suggesting that brain structures associated with P50 components may be important biomarkers of SCZ psychopathology. Future studies could use a prospective longitudinal design to investigate the potential causal relationship of brain structures associated with P50 components in the psychopathological symptoms of SCZ patients. |
收录类别 | SCI |
WOS关键词 | ACOUSTIC STARTLE MAGNITUDE ; NEGATIVE SYNDROME SCALE ; SUPPRESSION DEFICITS ; PREPULSE INHIBITION ; TEMPORAL GYRUS ; LATENCY ; ABNORMALITIES ; NEUROCOGNITION ; HERITABILITY ; ASSOCIATION |
资助项目 | Regional Science and Technology Development (Basic Research) Project[YDZJSX2022A064] ; Special Grant 136 of First Hospital of Shangxi Medical University Project[Y2022136006] ; Key Research and Development (R&D) Projects of Shanxi Province of China[201803D31098] ; Grant for clinical research by Wu Jieping Medical Foundation[320.6750.18336] |
WOS研究方向 | Psychiatry |
出版者 | ELSEVIER |
WOS记录号 | WOS:000911422100001 |
资助机构 | Regional Science and Technology Development (Basic Research) Project ; Special Grant 136 of First Hospital of Shangxi Medical University Project ; Key Research and Development (R&D) Projects of Shanxi Province of China ; Grant for clinical research by Wu Jieping Medical Foundation |
源URL | [http://ir.psych.ac.cn/handle/311026/44554] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Lang, XiaoE; Zhang, Xiang-Yang |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China 2.85 Jiefang Southern Rd, Taiyuan 030001, Shanxi, Peoples R China 3.Baylor Coll Med, Dept Psychiat, Houston, TX USA 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 6.Shanxi Med Univ, Dept Psychiat, Hosp 1, Taiyuan, Peoples R China |
推荐引用方式 GB/T 7714 | Lang, XiaoE,Wang, Dongmei,Zhou, Huixia,et al. P50 inhibition defects, psychopathology and gray matter volume in patients with first-episode drug-naive schizophrenia[J]. ASIAN JOURNAL OF PSYCHIATRY,2023,80:8. |
APA | Lang, XiaoE,Wang, Dongmei,Zhou, Huixia,Wang, Li,Kosten, Thomas R.,&Zhang, Xiang-Yang.(2023).P50 inhibition defects, psychopathology and gray matter volume in patients with first-episode drug-naive schizophrenia.ASIAN JOURNAL OF PSYCHIATRY,80,8. |
MLA | Lang, XiaoE,et al."P50 inhibition defects, psychopathology and gray matter volume in patients with first-episode drug-naive schizophrenia".ASIAN JOURNAL OF PSYCHIATRY 80(2023):8. |
入库方式: OAI收割
来源:心理研究所
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