Cellular alterations and crosstalk in the osteochondral joint in osteoarthritis and promising therapeutic strategies
文献类型：期刊论文
| 作者 | Jiang, Ai; Xu, Peng4; Sun, Shang; Zhao, Zhenda; Tan, Qizhao; Li, Weishi3; Song, Chunli2; Leng, Huijie |
| 刊名 | CONNECTIVE TISSUE RESEARCH
 |
| 出版日期 | 2021 |
| 卷号 | 62期号:6页码:709-719 |
| 关键词 | Osteoarthritis crosstalk cartilage chondrocytes osteoblasts osteocytes |
| ISSN号 | 0300-8207 |
| DOI | 10.1080/03008207.2020.1870969 |
| 文献子类 | Article |
| 英文摘要 | Osteoarthritis (OA) is a joint disorder involving cartilage degeneration and subchondral bone sclerosis. The bone-cartilage interface is implicated in OA pathogenesis due to its susceptibility to mechanical and biological factors. The crosstalk between cartilage and the underlying subchondral bone is elevated in OA due to multiple factors, such as increased vascularization, porosity, microcracks and fissures. Changes in the osteochondral joint are traceable to alterations in chondrocytes and bone cells (osteoblasts, osteocytes and osteoclasts). The phenotypes of these cells can change with the progression of OA. Aberrant intercellular communications among bone cell-bone cell and bone cell-chondrocyte are of great importance and might be factors OA development. An appreciation of cellular phenotypic changes in OA and the mechanisms by which these cells communicate would be expected to lead to the development of targeted drugs with fewer side effects. |
| 学科主题 | Cell Biology ; Orthopedics |
| 出版地 | PHILADELPHIA |
| 电子版国际标准刊号 | 1607-8438 |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000608312200001 |
| 出版者 | TAYLOR & FRANCIS INC |
| 资助机构 | National Natural Science Foundation of China [11872076, 11472017] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/26492]  |
| 专题 | 植物研究所_系统与进化植物学研究中心_系统与进化植物学研究中心_学位论文 |
| 作者单位 | 1.Beijing Key Lab Spine Dis, Beijing, Peoples R China 2.Minist Educ, Engn Res Ctr Bone & Joint Precis Med, Lisbon, Portugal 3.Chinese Acad Sci, State Key Lab Systemat & Evolutionary Bot, Inst Bot, Beijing, Peoples R China 4.Peking Univ Third Hosp, Dept Orthopaed, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Ai,Xu, Peng,Sun, Shang,et al. Cellular alterations and crosstalk in the osteochondral joint in osteoarthritis and promising therapeutic strategies[J]. CONNECTIVE TISSUE RESEARCH,2021,62(6):709-719. |
| APA | Jiang, Ai.,Xu, Peng.,Sun, Shang.,Zhao, Zhenda.,Tan, Qizhao.,...&Leng, Huijie.(2021).Cellular alterations and crosstalk in the osteochondral joint in osteoarthritis and promising therapeutic strategies.CONNECTIVE TISSUE RESEARCH,62(6),709-719. |
| MLA | Jiang, Ai,et al."Cellular alterations and crosstalk in the osteochondral joint in osteoarthritis and promising therapeutic strategies".CONNECTIVE TISSUE RESEARCH 62.6(2021):709-719. |
入库方式： OAI收割
来源：植物研究所
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