Callicarpa japonica Thunb. ameliorates allergic airway inflammation by suppressing NF-kappa B activation and upregulating HO-1 expression
文献类型：期刊论文
| 作者 | Kim, Seong-Man; Ryu, Hyung Won; Kwon, Ok-Kyoung; Hwang, Daseul; Kim, Min Gu; Min, Jae-Hong; Zhang, Zhiyun1; Kim, Soo-Yong; Paik, Jin-Hyub; Oh, Sei-Ryang |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2021 |
| 卷号 | 267 |
| 关键词 | Allergic asthma Callicarpa japonica Thunb. Th2 cytokines Eosinophil NF-kappa B HO-1 |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2020.113523 |
| 文献子类 | Article |
| 英文摘要 | Ethnopharmacological relevance: Callicarpa japonica Thunb., as an herbal medicine has been used for the treatment of inflammatory diseases in China and Korea. Materials and methods: Ultra performance liquid chromatography-photodiode array-quadrupole time-of-flight mass spectrometer (UPLC-PDA-QTof MS) was used to detect the major phenylethanoid glycosides in the C. japonica extract. BALB/c mice were intraperitoneally sensitized by ovalbumin (OVA) (on days 0 and 7) and challenged by OVA aerosol (on days 11-13) to induce airway inflammatory response. The mice were also administered with C. japonica Thunb. (CJT) (20 and 40 mg/kg Per oral) on days 9-13. CJT pretreatment was conducted in lipopolysaccharide (LPS)-stimulated RAW264.7 or phorbol 12-myristate 13-acetate (PMA)-stimulated A549 cells. Results: CJT administration significantly reduced the secretion of Th2 cytokines, TNF-alpha, IL-6, immunoglobulin E (IgE) and histamine, and the recruitment of eosinophils in an OVA-exposed mice. In histological analyses, the amelioration of inflammatory cell influx and mucus secretion were observed with CJT. The OVA-induced airway hyperresponsiveness (AHR), iNOS expression and NF-kappa B activation were effectively suppressed by CJT administration. In addition, CJT led to the upregulation of HO-1 expression. In an in vitro study, CJT pretreatment suppressed the LPS-induced TNF-alpha secretion in RAW264.7 cells and attenuated the PMA-induced IL-6, IL-8 and MCP-1 secretion in A549 cells. These effects were accompanied by downregulated NF-kappa B phosphorylation and by upregulated HO-1 expression. Conclusion: These results suggested that CJT has protective activity against OVA-induced airway inflammation via downregulation of NF-kappa B activation and upregulation of HO-1, suggesting that CJT has preventive potential for the development of allergic asthma. |
| 学科主题 | Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 出版地 | CLARE |
| 电子版国际标准刊号 | 1872-7573 |
| WOS关键词 | BRONCHIAL HYPERRESPONSIVENESS ; INDUCED ASTHMA ; TH2 CYTOKINES ; RESPONSES ; EXTRACT ; ALPHA ; MODEL ; CORTICOSTEROIDS ; INTERLEUKIN-6 ; PATHWAY |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000606369500003 |
| 出版者 | ELSEVIER IRELAND LTD |
| 资助机构 | Korea Research Institute of Bioscience and Biotechnology Research Initiative Program [KGM 5522012] ; Ministry of Health and Welfare of Republic of Korea [HI14C1277] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/26622]  |
| 专题 | 植物研究所_系统与进化植物学研究中心_系统与进化植物学研究中心_学位论文 |
| 作者单位 | 1.Chungbuk Natl Univ, Coll Pharm, Cheongju 28160, Chungcheongbuk, South Korea 2.Korea Res Inst Biosci & Biotechnol KRIBB, Nat Med Res Ctr, Chungbuk 28116, South Korea 3.Chungnam Natl Univ, Coll Pharm, 99 Daehak Ro, Daejeon 305764, South Korea 4.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 5.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, 125 Gwahak Ro, Daejeon 34141, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kim, Seong-Man,Ryu, Hyung Won,Kwon, Ok-Kyoung,et al. Callicarpa japonica Thunb. ameliorates allergic airway inflammation by suppressing NF-kappa B activation and upregulating HO-1 expression[J]. JOURNAL OF ETHNOPHARMACOLOGY,2021,267. |
| APA | Kim, Seong-Man.,Ryu, Hyung Won.,Kwon, Ok-Kyoung.,Hwang, Daseul.,Kim, Min Gu.,...&Lee, Jae-Won.(2021).Callicarpa japonica Thunb. ameliorates allergic airway inflammation by suppressing NF-kappa B activation and upregulating HO-1 expression.JOURNAL OF ETHNOPHARMACOLOGY,267. |
| MLA | Kim, Seong-Man,et al."Callicarpa japonica Thunb. ameliorates allergic airway inflammation by suppressing NF-kappa B activation and upregulating HO-1 expression".JOURNAL OF ETHNOPHARMACOLOGY 267(2021). |
入库方式： OAI收割
来源：植物研究所
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