JMJ27-mediated histone H3K9 demethylation positively regulates drought-stress responses in Arabidopsis
文献类型：期刊论文
| 作者 | Wang, Qiongli2; Liu, Peng; Jing, Hua3; Zhou, Xiao Feng4; Zhao, Bo; Li, Yuan; Jin, Jing Bo3 |
| 刊名 | NEW PHYTOLOGIST
 |
| 出版日期 | 2021 |
| 卷号 | 232期号:1页码:221-236 |
| 关键词 | Arabidopsis drought stress histone demethylase histone methylation |
| ISSN号 | 0028-646X |
| DOI | 10.1111/nph.17593 |
| 文献子类 | Article |
| 英文摘要 | Dimethylation of histone H3 at lysine 9 (H3K9me2) is associated with heterochromatinization and transcriptional gene silencing in plants. The activation of sets of genes by drought stress is correlated with reduced H3K9me2 levels, but the role of H3K9 methylation in the regulation of drought-stress responses remains elusive. Here, we show that the Jumonji domain-containing H3K9 demethylase JMJ27 positively regulates drought-stress responses through its histone demethylase activity. RNA-seq analysis identified JMJ27-regulated genes, including positive regulators of drought stress GALACTINOL SYNTHASE 2 (GOLS2) and RESPONSE TO DESICCATION 20 (RD20). Genetic analysis demonstrated that JMJ27 positively regulates drought-stress responses at least partly through GOLS2 and RD20. JMJ27 directly associated with GOLS2 and RD20, and protected these loci from silencing by reducing H3K9me2 levels under normal conditions. REGULATORY PARTICLE NON-ATPASE 1a (RPN1a), a subunit of the 26S proteasome, interacted with JMJ27 and negatively regulated JMJ27 accumulation. Drought stress diminished RPN1a abundance, resulting in increased JMJ27 abundance. The drought stress-promoted occupancy of JMJ27 at GOLS2 and RD20 chromatin may reinforce their transcriptional induction by locally reducing the H3K9me2 levels. These results indicate that the RPN1a-JMJ27 module precisely regulates dynamic H3K9me2 deposition plasticity, ensuring proper adaptation to drought stress in Arabidopsis. |
| 学科主题 | Plant Sciences |
| 出版地 | HOBOKEN |
| 电子版国际标准刊号 | 1469-8137 |
| WOS关键词 | DNA METHYLATION ; STOMATAL CLOSURE ; ABSCISIC-ACID ; JMJC DOMAIN ; PROTEIN ; ABA ; TRANSFORMATION ; TOLERANCE ; GENES |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000679482400001 |
| 出版者 | WILEY |
| 资助机构 | National Natural Science Foundation of China [31870238, 31900225] ; Chinese Academy of Sciences [XDA24010105-2, ZDRW-ZS-2019-2-0101, KFJ-STS-ZDTP-076-1] ; Chinese Academy of Sciences (Innovative Academy of Seed Design) |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/26396]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.China Agr Univ, Dept Ornamental Hort, Beijing 100193, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China 3.Fujian Agr & Forestry Univ, Coll Agr, Breeding & Multiple Utilizat Crops, Key Lab,Minist Educ Genet, Fuzhou 350002, Fujian, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qiongli,Liu, Peng,Jing, Hua,et al. JMJ27-mediated histone H3K9 demethylation positively regulates drought-stress responses in Arabidopsis[J]. NEW PHYTOLOGIST,2021,232(1):221-236. |
| APA | Wang, Qiongli.,Liu, Peng.,Jing, Hua.,Zhou, Xiao Feng.,Zhao, Bo.,...&Jin, Jing Bo.(2021).JMJ27-mediated histone H3K9 demethylation positively regulates drought-stress responses in Arabidopsis.NEW PHYTOLOGIST,232(1),221-236. |
| MLA | Wang, Qiongli,et al."JMJ27-mediated histone H3K9 demethylation positively regulates drought-stress responses in Arabidopsis".NEW PHYTOLOGIST 232.1(2021):221-236. |
入库方式： OAI收割
来源：植物研究所
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