BBX19 fine-tunes the circadian rhythm by interacting with PSEUDO-RESPONSE REGULATOR proteins to facilitate their repressive effect on morning-phased clock genes
文献类型：期刊论文
| 作者 | Yuan, Li; Yu, Yingjun2,3; Liu, Mingming; Song, Yang; Li, Hongmin; Sun, Junqiu; Wang, Qiao1; Xie, Qiguang; Wang, Lei2 ; Xu, Xiaodong
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| 刊名 | PLANT CELL
 |
| 出版日期 | 2021 |
| 卷号 | 33期号:8页码:2602-2617 |
| ISSN号 | 1040-4651 |
| DOI | 10.1093/plcell/koab133 |
| 文献子类 | Article |
| 英文摘要 | The core plant circadian oscillator is composed of multiple interlocked transcriptional-translational feedback loops, which synchronize endogenous diel physiological rhythms to the cyclic changes of environmental cues. PSEUDO-RESPONSE REGULATORS (PRRs) have been identified as negative components in the circadian clock, though their underlying molecular mechanisms remain largely unknown. Here, we found that a subfamily of zinc finger transcription factors, B-box (BBX)-containing proteins, have a critical role in fine-tuning circadian rhythm. We demonstrated that overexpressing Arabidopsis thaliana BBX19 and BBX18 significantly lengthened the circadian period, while the null mutation of BBX19 accelerated the circadian speed. Moreover, BBX19 and BBX18, which are expressed during the day, physically interacted with PRR9, PRR7, and PRR5 in the nucleus in precise temporal ordering from dawn to dusk, consistent with the respective protein accumulation pattern of PRRs. Our transcriptomic and genetic analysis indicated that BBX19 and PRR9, PRR7, and PRR5 cooperatively inhibited the expression of morning-phased clock genes. PRR proteins affected BBX19 recruitment to the CCA1, LHY, and RVE8 promoters. Collectively, our findings show that BBX19 interacts with PRRs to orchestrate circadian rhythms, and suggest the indispensable role of transcriptional regulators in fine-tuning the circadian clock. |
| 学科主题 | Biochemistry & Molecular Biology ; Plant Sciences ; Cell Biology |
| 出版地 | CARY |
| 电子版国际标准刊号 | 1532-298X |
| WOS关键词 | B-BOX PROTEIN ; TRANSCRIPTIONAL REPRESSION ; FLOWERING TIME ; ARABIDOPSIS ; ELF3 ; LIGHT ; CCA1 ; HY5 ; EXPRESSION ; COP1 |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000696248800012 |
| 出版者 | OXFORD UNIV PRESS INC |
| 资助机构 | National Natural Science Foundation of China [U1904202, 31570285, 31670285, 31570292] ; Natural Science Foundation of Hebei [17966304D] ; Hebei Hundred Talents Program [E2016100018] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB27030206] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/26414]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Henan Univ, Sch Life Sci, State Key Lab Crop Stress Adaptat & Improvement, Kaifeng 475004, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China 4.Hebei Normal Univ, Coll Life Sci, Shijiazhuang 050024, Hebei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Li,Yu, Yingjun,Liu, Mingming,et al. BBX19 fine-tunes the circadian rhythm by interacting with PSEUDO-RESPONSE REGULATOR proteins to facilitate their repressive effect on morning-phased clock genes[J]. PLANT CELL,2021,33(8):2602-2617. |
| APA | Yuan, Li.,Yu, Yingjun.,Liu, Mingming.,Song, Yang.,Li, Hongmin.,...&Xu, Xiaodong.(2021).BBX19 fine-tunes the circadian rhythm by interacting with PSEUDO-RESPONSE REGULATOR proteins to facilitate their repressive effect on morning-phased clock genes.PLANT CELL,33(8),2602-2617. |
| MLA | Yuan, Li,et al."BBX19 fine-tunes the circadian rhythm by interacting with PSEUDO-RESPONSE REGULATOR proteins to facilitate their repressive effect on morning-phased clock genes".PLANT CELL 33.8(2021):2602-2617. |
入库方式： OAI收割
来源：植物研究所
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