The ubiquitin-interacting motif-type ubiquitin receptor HDR3 interacts with and stabilizes the histone acetyltransferase GW6a to control the grain size in rice
文献类型：期刊论文
| 作者 | Gao, Qiong; Zhang, Ning; Wang, Wei-Qing; Shen, Shao-Yan; Bai, Chen; Song, Xian-Jun
|
| 刊名 | PLANT CELL
 |
| 出版日期 | 2021 |
| 卷号 | 33期号:10页码:3331-3347 |
| ISSN号 | 1040-4651 |
| DOI | 10.1093/plcell/koab194 |
| 文献子类 | Article |
| 英文摘要 | For grain crops such as rice (Oryza sativa), grain size substantially affects yield. The histone acetyltransferase GRAIN WEIGHT 6a (GW6a) determines grain size and yield in rice. However, the gene regulatory network underlying GW6a-mediated regulation of grain size has remained elusive. In this study, we show that GW6a interacts with HOMOLOG OF DA1 ON RICE CHROMOSOME 3 (HDR3), a ubiquitin-interacting motif-containing ubiquitin receptor. Transgenic rice plants overexpressing HDR3 produced larger grains, whereas HDR3 knockout lines produce smaller grains compared to the control. Cytological data suggest that HDR3 modulates grain size in a similar manner to GW6a, by altering cell proliferation in spikelet hulls. Mechanistically, HDR3 physically interacts with and stabilizes GW6a in an ubiquitin-dependent manner, delaying protein degradation by the 26S proteasome. The delay in GW6a degradation results in dramatic enhancement of the local acetylation of H3 and H4 histones. Furthermore, RNA sequencing analysis and chromatin immunoprecipitation assays reveal that HDR3 and GW6a bind to the promoters of and modulate a common set of downstream genes. In addition, genetic analysis demonstrates that HDR3 functions in the same genetic pathway as GW6a to regulate the grain size. Therefore, we identified the grain size regulatory module HDR3-GW6a as a potential target for crop yield improvement. |
| 学科主题 | Biochemistry & Molecular Biology ; Plant Sciences ; Cell Biology |
| 出版地 | CARY |
| 电子版国际标准刊号 | 1532-298X |
| WOS关键词 | ORGAN SIZE ; MULTIUBIQUITIN CHAIN ; NATURAL VARIATION ; RARE ALLELE ; BINDING ; YIELD ; DA1 ; WEIGHT ; SEED ; DEGRADATION |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000711392400015 |
| 出版者 | OXFORD UNIV PRESS INC |
| 资助机构 | Chinese Academy of Sciences [XDA24010101-2] ; National Key Research and Development Program of China [2016YFD0100402] ; National Natural Science Foundation of China [91735302, 91435113, 31471466] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/26428]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Innovat Acad Seed Design, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Coll Adv Agr Sci, Beijing 100049, Peoples R China 3.[Gao, Qiong 4.Zhang, Ning 5.Wang, Wei-Qing 6.Shen, Shao-Yan 7.Bai, Chen 8.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, 20 Nanxincun, Beijing 100093, Peoples R China 9.[Zhang, Ning |
| 推荐引用方式 GB/T 7714 | Gao, Qiong,Zhang, Ning,Wang, Wei-Qing,et al. The ubiquitin-interacting motif-type ubiquitin receptor HDR3 interacts with and stabilizes the histone acetyltransferase GW6a to control the grain size in rice[J]. PLANT CELL,2021,33(10):3331-3347. |
| APA | Gao, Qiong,Zhang, Ning,Wang, Wei-Qing,Shen, Shao-Yan,Bai, Chen,&Song, Xian-Jun.(2021).The ubiquitin-interacting motif-type ubiquitin receptor HDR3 interacts with and stabilizes the histone acetyltransferase GW6a to control the grain size in rice.PLANT CELL,33(10),3331-3347. |
| MLA | Gao, Qiong,et al."The ubiquitin-interacting motif-type ubiquitin receptor HDR3 interacts with and stabilizes the histone acetyltransferase GW6a to control the grain size in rice".PLANT CELL 33.10(2021):3331-3347. |
入库方式： OAI收割
来源：植物研究所
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