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SDC mediates DNA methylation-controlled clock pace by interacting with ZTL in Arabidopsis

文献类型：期刊论文

作者Tian, Wenwen1; Wang, Ruyi; Bo, Cunpei1; Yu, Yingjun1; Zhang, Yuanyuan; Shin, Gyeong-Im; Kim, Woe-Yeon; Wang, Lei1
刊名NUCLEIC ACIDS RESEARCH
出版日期2021
卷号49期号:7页码:3764-3780
ISSN号0305-1048
DOI10.1093/nar/gkab128
文献子类Article
英文摘要Molecular bases of eukaryotic circadian clocks mainly rely on transcriptional-translational feedback loops (TTFLs), while epigenetic codes also play critical roles in fine-tuning circadian rhythms. However, unlike histone modification codes that play extensive and well-known roles in the regulation of circadian clocks, whether DNA methylation (5mC) can affect the circadian clock, and the associated underlying molecular mechanisms, remains largely unexplored in many organisms. Here we demonstrate that global genome DNA hypomethylation can significantly lengthen the circadian period of Arabidopsis. Transcriptomic and genetic evidence demonstrate that SUPPRESSOR OF drm1 drm2 cmt3 (SDC), encoding an F-box containing protein, is required for the DNA hypomethylation-tuned circadian clock. Moreover, SDC can physically interact with another F-box containing protein ZEITLUPE (ZTL) to diminish its accumulation. Genetic analysis further revealed that ZTL and its substrate TIMING OF CAB EXPRESSION 1 (TOC1) likely act downstream of DNA methyltransferases to control circadian rhythm. Together, our findings support the notion that DNA methylation is important to maintain proper circadian pace in Arabidopsis, and further established that SDC links DNA hypomethylation with a proteolytic cascade to assist in tuning the circadian clock.
学科主题Biochemistry & Molecular Biology
出版地OXFORD
电子版国际标准刊号1362-4962
WOS关键词PSEUDO-RESPONSE REGULATORS ; NATURAL ALLELIC VARIATION ; CIRCADIAN CLOCK ; POSTTRANSLATIONAL REGULATION ; TARGETED DEGRADATION ; LEAF SENESCENCE ; COMPLEX ; PLANT ; GROWTH ; TOC1
WOS研究方向Science Citation Index Expanded (SCI-EXPANDED)
语种英语
WOS记录号WOS:000649006000019
出版者OXFORD UNIV PRESS
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences [XDB27030206] ; National Natural Science Foundation of China [31570292] ; Chinese Academy of Sciences [XDB27030206] ; Priority Research Program of the Chinese Academy of Sciences [XDB27030206]
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/26440]  
专题中科院植物分子生理学重点实验室
作者单位1.Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Gyeongsang Natl Univ, Res Inst Life Sci RILS, Div Appl Life Sci BK21Plus, Jinju 52828, South Korea
4.Gyeongsang Natl Univ, Inst Agr & Life Sci IALS, Jinju 52828, South Korea
推荐引用方式
GB/T 7714		 Tian, Wenwen,Wang, Ruyi,Bo, Cunpei,et al. SDC mediates DNA methylation-controlled clock pace by interacting with ZTL in Arabidopsis[J]. NUCLEIC ACIDS RESEARCH,2021,49(7):3764-3780.
APA Tian, Wenwen.,Wang, Ruyi.,Bo, Cunpei.,Yu, Yingjun.,Zhang, Yuanyuan.,...&Wang, Lei.(2021).SDC mediates DNA methylation-controlled clock pace by interacting with ZTL in Arabidopsis.NUCLEIC ACIDS RESEARCH,49(7),3764-3780.
MLA Tian, Wenwen,et al."SDC mediates DNA methylation-controlled clock pace by interacting with ZTL in Arabidopsis".NUCLEIC ACIDS RESEARCH 49.7(2021):3764-3780.

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来源：植物研究所

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