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NCP2/RHD4/SAC7, SAC6 and SAC8 phosphoinositide phosphatases are required for PtdIns4P and PtdIns(4,5)P2 homeostasis and Arabidopsis development

文献类型：期刊论文

作者Song, Lizhen; Wang, Yanning2; Guo, Zhiai; Lam, Sin M.; Shui, Guanghou3; Cheng, Youfa2,4
刊名NEW PHYTOLOGIST
出版日期2021
卷号231期号:2页码:713-725
关键词auxin embryo development protein trafficking PtdIns(4 5)P2 PtdIns4P SAC phosphoinositide phosphatases
ISSN号0028-646X
DOI10.1111/nph.17402
文献子类Article
英文摘要Phosphoinositides play important roles in plant growth and development. Several SAC domain phosphoinositide phosphatases have been reported to be important for plant development. Here, we show functional analysis of SUPPRESSOR OF ACTIN 6 (SAC6) to SAC8 in Arabidopsis, a subfamily of phosphoinositide phosphatases containing SAC-domain and two transmembrane motifs. We isolated an Arabidopsis mutant ncp2 that lacked cotyledons in seedling and embryo in pid, a background defective in auxin signaling and transport. NCP2 encodes RHD4/SAC7 phosphoinositide phosphatase. SAC6, SAC7 and SAC8 exhibit overlapping and specific expression patterns in seedling and embryo. The sac6 sac7 embryos either fail to develop into seeds, or have three or four cotyledons. The embryo development of sac7 sac8 and sac6 sac7 sac8 mutants is significantly delayed or lethal, and the seedlings are arrested at early stages. Auxin maxima are decreased in double and triple sac mutants. The contents of PtdIns4P and PtdIns(4,5)P2 in sac6 sac7 and sac7 sac8 mutants are dramatically increased. Protein trafficking of the plasma membrane (PM)-localized protein PIN1 and PIN2 from trans-Golgi network/early endosome back to PM is delayed in sac7 sac8 mutants. These results indicate that SAC6-SAC8 are essential for maintaining homeostasis of PtdIns4P and PtdIns(4,5)P2, and auxin-mediated development in Arabidopsis.
学科主题Plant Sciences
出版地HOBOKEN
电子版国际标准刊号1469-8137
WOS关键词AUXIN TRANSPORT ; PLASMA-MEMBRANE ; YEAST SAC1 ; PHOSPHORYLATION ; EXPRESSION
WOS研究方向Science Citation Index Expanded (SCI-EXPANDED)
语种英语
WOS记录号WOS:000650952700001
出版者WILEY
资助机构National Natural Science Foundation of China (NSFC) [31970309, 91217310] ; National Key Research and Development Program of China [2016YFD0100400] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA26030302] ; STS Program of the Chinese Academy of Sciences (STS Program) [KFJ-STS-ZDTP-076] ; National Basic Research Program of China [2014CB943400]
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/26493]  
专题中科院植物分子生理学重点实验室
作者单位1.Chinese Acad Sci, Innovat Acad Seed Design, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Song, Lizhen,Wang, Yanning,Guo, Zhiai,et al. NCP2/RHD4/SAC7, SAC6 and SAC8 phosphoinositide phosphatases are required for PtdIns4P and PtdIns(4,5)P2 homeostasis and Arabidopsis development[J]. NEW PHYTOLOGIST,2021,231(2):713-725.
APA Song, Lizhen,Wang, Yanning,Guo, Zhiai,Lam, Sin M.,Shui, Guanghou,&Cheng, Youfa.(2021).NCP2/RHD4/SAC7, SAC6 and SAC8 phosphoinositide phosphatases are required for PtdIns4P and PtdIns(4,5)P2 homeostasis and Arabidopsis development.NEW PHYTOLOGIST,231(2),713-725.
MLA Song, Lizhen,et al."NCP2/RHD4/SAC7, SAC6 and SAC8 phosphoinositide phosphatases are required for PtdIns4P and PtdIns(4,5)P2 homeostasis and Arabidopsis development".NEW PHYTOLOGIST 231.2(2021):713-725.

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来源：植物研究所

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