DNA Methyltransferases Regulate Pathogenicity of Botrytis cinerea to Horticultural Crops
文献类型：期刊论文
| 作者 | Zhang, Zhanquan2; He, Chang2; Chen, Yong; Li, Boqiang; Tian, Shiping2
|
| 刊名 | JOURNAL OF FUNGI
 |
| 出版日期 | 2021 |
| 卷号 | 7期号:8 |
| 关键词 | Botrytis cinerea DNA methyltransferases synergistic effect pathogenicity development |
| DOI | 10.3390/jof7080659 |
| 文献子类 | Article |
| 英文摘要 | Botrytis cinerea is one of the most destructive fungal pathogens that cause gray mold rot in horticultural products, including fresh fruits, vegetables, and flowers, leading to serious economic losses. B. cinerea is difficult to control because it has strong stress resistance and complex infection modes. The pathogenic mechanisms of B. cinerea have been revealed at multiple levels, but little is known at the epigenetic level. In this study, we first revealed the important role of DNA methyltransferases in regulating the development and pathogenicity of B. cinerea. We showed that two DNA methyltransferases, BcDIM2 and BcRID2, showed a strong synergistic effect in regulating the pathogenicity of B. cinerea. The double knockout mutant Delta Bcdim2rid2 showed slower mycelial growth, lower spore germination, attenuated oxidative tolerance, and complete pathogenicity loss on various hosts, which is related to the reduced expression of virulence-related genes in Delta Bcdim2rid2 and the induced resistance of the host. Although B. cinerea has multiple DNA methyltransferases, the global methylation level is very low, and few 5mC sites can be detected by BS-seq. These results first revealed the important role and the action mode of DNA methyltransferases in B. cinerea. |
| 学科主题 | Microbiology ; Mycology |
| 出版地 | BASEL |
| 电子版国际标准刊号 | 2309-608X |
| WOS关键词 | INDUCED POINT MUTATION ; METHYLATION PATTERNS ; PLANT-PATHOGEN ; VIRULENCE ; GENE ; DIFFERENTIATION ; ARABIDOPSIS ; EXPRESSION ; COMPONENT ; REVEALS |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000690558200001 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation of China [31930086, 31972475, 31722043] ; Youth Innovation Promotion Association CAS [2018107] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/26538]  |
| 专题 | 中科院北方资源植物重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhanquan,He, Chang,Chen, Yong,et al. DNA Methyltransferases Regulate Pathogenicity of Botrytis cinerea to Horticultural Crops[J]. JOURNAL OF FUNGI,2021,7(8). |
| APA | Zhang, Zhanquan,He, Chang,Chen, Yong,Li, Boqiang,&Tian, Shiping.(2021).DNA Methyltransferases Regulate Pathogenicity of Botrytis cinerea to Horticultural Crops.JOURNAL OF FUNGI,7(8). |
| MLA | Zhang, Zhanquan,et al."DNA Methyltransferases Regulate Pathogenicity of Botrytis cinerea to Horticultural Crops".JOURNAL OF FUNGI 7.8(2021). |
入库方式： OAI收割
来源：植物研究所
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