Arginine Methyltransferase PeRmtC Regulates Development and Pathogenicity of Penicillium expansum via Mediating Key Genes in Conidiation and Secondary Metabolism
文献类型：期刊论文
| 作者 | Xu, Xiaodi2; Chen, Yong; Li, Boqiang; Tian, Shiping2
|
| 刊名 | JOURNAL OF FUNGI
 |
| 出版日期 | 2021 |
| 卷号 | 7期号:10 |
| 关键词 | Penicillium expansum protein arginine methyltransferase development pathogenicity metabolism regulation |
| DOI | 10.3390/jof7100807 |
| 文献子类 | Article |
| 英文摘要 | Penicillium expansum is one of the most common and destructive post-harvest fungal pathogens that can cause blue mold rot and produce mycotoxins in fruit, leading to significant post-harvest loss and food safety concerns. Arginine methylation by protein arginine methyltransferases (PRMTs) modulates various cellular processes in many eukaryotes. However, the functions of PRMTs are largely unknown in post-harvest fungal pathogens. To explore their roles in P. expansum, we identified four PRMTs (PeRmtA, PeRmtB, PeRmtC, and PeRmt2). The single deletion of PeRmtA, PeRmtB, or PeRmt2 had minor or no impact on the P. expansum phenotype while deletion of PeRmtC resulted in decreased conidiation, delayed conidial germination, impaired pathogenicity and pigment biosynthesis, and altered tolerance to environmental stresses. Further research showed that PeRmtC could regulate two core regulatory genes, PeBrlA and PeAbaA, in conidiation, a series of backbone genes in secondary metabolism, and affect the symmetric omega-N-G, N'(G)-dimethylarginine (sDMA) modification of proteins with molecular weights of primarily 16-17 kDa. Collectively, this work functionally characterized four PRMTs in P. expansum and showed the important roles of PeRmtC in the development, pathogenicity, and secondary metabolism of P. expansum. |
| 学科主题 | Microbiology ; Mycology |
| 出版地 | BASEL |
| 电子版国际标准刊号 | 2309-608X |
| WOS关键词 | DISTINCT STAGES ; METHYLATION ; EXPRESSION ; PATULIN ; BIOSYNTHESIS ; REVEALS ; CULTURE ; ABAA |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000713191500001 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation of China [31930086, 32072273, 32002099] ; Youth Innovation Promotion Association CAS [Y201919] ; China Postdoctoral Science Foundation [2020M670523] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/26555]  |
| 专题 | 中科院北方资源植物重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Innovat Acad Seed Design, Inst Bot, Key Lab Plant Resources, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xiaodi,Chen, Yong,Li, Boqiang,et al. Arginine Methyltransferase PeRmtC Regulates Development and Pathogenicity of Penicillium expansum via Mediating Key Genes in Conidiation and Secondary Metabolism[J]. JOURNAL OF FUNGI,2021,7(10). |
| APA | Xu, Xiaodi,Chen, Yong,Li, Boqiang,&Tian, Shiping.(2021).Arginine Methyltransferase PeRmtC Regulates Development and Pathogenicity of Penicillium expansum via Mediating Key Genes in Conidiation and Secondary Metabolism.JOURNAL OF FUNGI,7(10). |
| MLA | Xu, Xiaodi,et al."Arginine Methyltransferase PeRmtC Regulates Development and Pathogenicity of Penicillium expansum via Mediating Key Genes in Conidiation and Secondary Metabolism".JOURNAL OF FUNGI 7.10(2021). |
入库方式： OAI收割
来源：植物研究所
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