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Extensive variation within the pan-genome of cultivated and wild sorghum

文献类型：期刊论文

作者Tao, Yongfu; Luo, Hong4; Xu, Jiabao3; Cruickshank, Alan2; Zhao, Xianrong; Teng, Fei3; Hathorn, Adrian; Wu, Xiaoyuan4; Liu, Yuanming1,4; Shatte, Tracey2
刊名NATURE PLANTS
出版日期2021
卷号7期号:6页码:766-773
ISSN号2055-026X
DOI10.1038/s41477-021-00925-x
文献子类Article
英文摘要Sorghum is a drought-tolerant staple crop for half a billion people in Africa and Asia, an important source of animal feed throughout the world and a biofuel feedstock of growing importance. Cultivated sorghum and its inter-fertile wild relatives constitute the primary gene pool for sorghum. Understanding and characterizing the diversity within this valuable resource is fundamental for its effective utilization in crop improvement. Here, we report analysis of a sorghum pan-genome to explore genetic diversity within the sorghum primary gene pool. We assembled 13 genomes representing cultivated sorghum and its wild relatives, and integrated them with 3 other published genomes to generate a pan-genome of 44,079 gene families with 222.6 Mb of new sequence identified. The pan-genome displays substantial gene-content variation, with 64% of gene families showing presence/absence variation among genomes. Comparisons between core genes and dispensable genes suggest that dispensable genes are important for sorghum adaptation. Extensive genetic variation was uncovered within the pan-genome, and the distribution of these variations was influenced by variation of recombination rate and transposable element content across the genome. We identified presence/absence variants that were under selection during sorghum domestication and improvement, and demonstrated that such variation had important phenotypic outcomes that could contribute to crop improvement. The constructed sorghum pan-genome represents an important resource for sorghum improvement and gene discovery. A sorghum pan-genome generated from 16 genomes representing cultivated and wild sorghum shows extensive variation, with 64% of the gene families exhibiting presence/absence variations, some of which confer phenotypic outcomes and contribute to domestication and improvement.
学科主题Plant Sciences
出版地BERLIN
电子版国际标准刊号2055-0278
WOS关键词GENE PREDICTION ; DOMESTICATION ; DIVERSITY ; EVOLUTION ; MODEL
WOS研究方向Science Citation Index Expanded (SCI-EXPANDED)
语种英语
WOS记录号WOS:000652425600001
出版者NATURE PORTFOLIO
资助机构Government of Norway ; Australian Research Council through the Centre of Excellence for Translational Photosynthesis [CE1401000015] ; National Key R&D Program of China [2019YFD1002701, 2018YFD1000701] ; Strategic Priority Research Program of Chinese Academy of Sciences [XDA26050101]
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/26586]  
专题中科院北方资源植物重点实验室
作者单位1.Agrisci Queensland, Dept Agr & Fisheries DAF, Hermitage Res Facil, Warwick, Qld, Australia
2.BGI Shenzhen, BGI Genom, Shenzhen, Peoples R China
3.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing, Peoples R China
4.Univ Queensland, Hermitage Res Facil, Queensland Alliance Agr & Food Innovat QAAFI, Warwick, Qld, Australia
5.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Tao, Yongfu,Luo, Hong,Xu, Jiabao,et al. Extensive variation within the pan-genome of cultivated and wild sorghum[J]. NATURE PLANTS,2021,7(6):766-773.
APA Tao, Yongfu.,Luo, Hong.,Xu, Jiabao.,Cruickshank, Alan.,Zhao, Xianrong.,...&Mace, Emma.(2021).Extensive variation within the pan-genome of cultivated and wild sorghum.NATURE PLANTS,7(6),766-773.
MLA Tao, Yongfu,et al."Extensive variation within the pan-genome of cultivated and wild sorghum".NATURE PLANTS 7.6(2021):766-773.

入库方式： OAI收割

来源：植物研究所

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