Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions
文献类型：期刊论文
| 作者 | Luo, Lu; Wang, Bo9; Jiang, Jingwen3; Fitzgerald, Martin4; Huang, Qin; Yu, Zheng5; Li, Hui1; Zhang, Jiqing; Wei, Jianhe2; Yang, Chenyuyan8 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2021 |
| 卷号 | 11 |
| 关键词 | heavy metal risk assessment safety and quality herbal mecidine extrinsic contamination |
| DOI | 10.3389/fphar.2020.595335 |
| 文献子类 | Article |
| 英文摘要 | Heavy metal contamination in herbal medicines is a global threat to human beings especially at levels above known threshold concentrations. The concentrations of five heavy metals cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg) and copper (Cu) were investigated using Inductively Coupled Plasma Optical Mass Spectrometry (ICP-MS) with 1773 samples around the world. According to Chinese Pharmacopoeia, 30.51% (541) samples were detected with at least one over-limit metal. The over-limit ratio for Pb was 5.75% (102), Cd at 4.96% (88), As at 4.17% (74), Hg at 3.78% (67), and of Cu, 1.75% (31). For exposure assessment, Pb, Cd, As, and Hg have resulted in higher than acceptable risks in 25 kinds of herbs. The maximal Estimated Daily Intake of Pb in seven herbs, of Cd in five, of Hg in four, and As in three exceeded their corresponding Provisional Tolerable Daily Intakes. In total 25 kinds of herbs present an unacceptable risk as assessed with the Hazard Quotient or Hazard Index. Additionally, the carcinogenic risks were all under acceptable limits. Notably, As posed the highest risk in all indicators including Estimated Daily Intake, Hazard Index, and carcinogenic risks. Therefore further study on enrichment effect of different states of As and special attention to monitoring shall be placed on As related contamination. |
| 学科主题 | Pharmacology & Pharmacy |
| 电子版国际标准刊号 | 1663-9812 |
| 出版地 | LAUSANNE |
| WOS关键词 | ICP-MS ; PLANTS ; HAZARDS ; SOILS |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000612207900001 |
| 资助机构 | Beijing Nova Program [Z181100006218020] ; Fundamental Research Funds for the central public welfare research institutes [ZZ13-AQ-049] ; Major science and technology projects of Yunnan province [2018ZF011] ; National Key RD Plan [2018YFC1706302] ; National Science and Technology Major Project for Significant New Drugs Development [2019ZX09201005-006001] ; National Natural Science Foundation [81973429] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/26614]  |
| 专题 | 中科院北方资源植物重点实验室 |
| 作者单位 | 1.Chengdu Univ Tradit Chinese Med, Coll Med Informat & Engn, Chengdu, Peoples R China 2.Chinese Acad Sci, Inst Bot, Beijing, Peoples R China 3.Hubei Inst Drug Control, Wuhan, Peoples R China 4.Sichuan Univ, West China Hosp, West China Biomed Big Data Ctr, Chengdu, Peoples R China 5.Univ Westminster, Dept Life Sci, London, England 6.Akupunktur Akad, Hovedgaard, Denmark 7.Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Informat, Beijing, Peoples R China 8.Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Hainan Branch, Hainan Prov Key Lab Resources Conservat & Dev Sou, Haikou, Hainan, Peoples R China 9.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Lu,Wang, Bo,Jiang, Jingwen,et al. Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions[J]. FRONTIERS IN PHARMACOLOGY,2021,11. |
| APA | Luo, Lu.,Wang, Bo.,Jiang, Jingwen.,Fitzgerald, Martin.,Huang, Qin.,...&Chen, Shilin.(2021).Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions.FRONTIERS IN PHARMACOLOGY,11. |
| MLA | Luo, Lu,et al."Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions".FRONTIERS IN PHARMACOLOGY 11(2021). |
入库方式： OAI收割
来源：植物研究所
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