Evaluation of the oxidation stability and anti-cancer cell activity of Paeonia ostii seed oil and its linolenic acid fractions delivered as microemulsions
文献类型：期刊论文
| 作者 | Wang, Xue; Zan, Mingyang; Amuti, Aibibai; Shu, Qingyan1; Wang, Zhanzhong |
| 刊名 | JOURNAL OF MOLECULAR LIQUIDS
 |
| 出版日期 | 2021 |
| 卷号 | 342 |
| 关键词 | Microemulsion Paeonia ostii seed oil alpha-linolenic acid Oxidation stability Oxidative stress |
| ISSN号 | 0167-7322 |
| DOI | 10.1016/j.molliq.2021.117579 |
| 文献子类 | Article |
| 英文摘要 | In this study, oil-in-water microemulsions (MEs) were developed and used as a stable carrier for delivery of Paeonia ostii seed oil (PSO), a fatty acid mixture (FAM), and alpha-linolenic acid (ALA). Dynamic light scattering (DLS) was used to measure the particle size and polydispersity index (PDI) of the ME. The effects of temperature, exposure to light, and the addition of antioxidants on the peroxide values of the loads were investigated. The MEs were composed of droplets with diameters between 15 and 35 nm and PDIs lower than 0.5, and the addition of antioxidants had no significant effect on the particle size and dispersibility. Temperature, more than light, was the factor that most significantly promoted doxidation, and the influence of the addition of different antioxidants was higher by butylated hydroxytoluene (BHT), followed by vitamin C and vitamin E. Viability and morphology of A549 human lung adenocarcinoma cells treated with MEs were studied. The three evaluated MEs caused damage to cell membrane and inhibited the growth of cancer cells in a dose-dependent manner. Data on intracellular malondialdehyde (MDA) content and superoxide dismutase (SOD) activity in cancer cells indicated that the treatment with MEs stimulated oxidative stress response and induced oxidative damage. These findings showed the latent capacity of MEs for protection of nutritional factors and for drug delivery. (C) 2021 Elsevier B.V. All rights reserved. |
| 学科主题 | Chemistry, Physical ; Physics, Atomic, Molecular & Chemical |
| 出版地 | AMSTERDAM |
| 电子版国际标准刊号 | 1873-3166 |
| WOS关键词 | FATTY-ACIDS ; ANTIOXIDANT ACTIVITY ; VEGETABLE-OILS ; TEMPERATURE ; DESIGN ; LIGHT |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000700317100114 |
| 出版者 | ELSEVIER |
| 资助机构 | Strategic Priority Research Program of the Chinese Academy of Sciences [XDA23080601] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/26786]  |
| 专题 | 中科院北方资源植物重点实验室 |
| 作者单位 | 1.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing Bot Garden, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xue,Zan, Mingyang,Amuti, Aibibai,et al. Evaluation of the oxidation stability and anti-cancer cell activity of Paeonia ostii seed oil and its linolenic acid fractions delivered as microemulsions[J]. JOURNAL OF MOLECULAR LIQUIDS,2021,342. |
| APA | Wang, Xue,Zan, Mingyang,Amuti, Aibibai,Shu, Qingyan,&Wang, Zhanzhong.(2021).Evaluation of the oxidation stability and anti-cancer cell activity of Paeonia ostii seed oil and its linolenic acid fractions delivered as microemulsions.JOURNAL OF MOLECULAR LIQUIDS,342. |
| MLA | Wang, Xue,et al."Evaluation of the oxidation stability and anti-cancer cell activity of Paeonia ostii seed oil and its linolenic acid fractions delivered as microemulsions".JOURNAL OF MOLECULAR LIQUIDS 342(2021). |
入库方式： OAI收割
来源：植物研究所
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