Metabolic characteristics, prevalence of anxiety and its influencing factors in first-episode and drug-na?ve major depressive disorder patients with impaired fasting glucose
文献类型:期刊论文
作者 | Wang, Qianjin4,5; Li, Yifan4,5; Ren, Honghong3,4,5; Huang, Qiuping4,5; Wang, Xuyi4,5; Zhou, Yanan4,5; Wu, Qiuxia4,5; Liu, Yueheng4,5; Li, Manyun4,5; Wang, Yunfei4,5 |
刊名 | JOURNAL OF AFFECTIVE DISORDERS |
出版日期 | 2023-03-01 |
卷号 | 324页码:341-348 |
通讯作者邮箱 | zhangxy@psych.ac.cn (x. zhang) |
ISSN号 | 0165-0327 |
关键词 | Major depressive disorder First -episode and drug -na?ve Anxiety symptoms Impaired fasting glucose Metabolism |
DOI | 10.1016/j.jad.2022.12.096 |
产权排序 | 4 |
文献子类 | 实证研究 |
英文摘要 | Background: Both major depressive disorder (MDD) and impaired fasting glucose (IFG) are associated with metabolic abnormalities and anxiety, but few studies have investigated the relationship between abnormal metabolism and anxiety in first-episode and drug-naive (FEDN) MDD patients with IFG. This study investigated the psychological status, metabolic properties, the prevalence and influencing factors of anxiety symptoms in the FEDN MDD patients with IFG. Methods: A total of 1718 FEDN MDD outpatients were recruited. Sociodemographic and suicide data were collected for each participant. The Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Rating Scale (HAMA) were used to assess patients' clinical symptoms. Fasting blood glucose, lipids, body mass index (BMI), and thyroid function-related indicators were also measured. Results: FEDN MDD patients with IFG (IFG group) had higher psychotic symptoms, suicide attempts, HAMD score, and HAMA score than FEDN MDD patients without IFG (NIFG group). There were also significant dif-ferences in blood lipids, BMI, and thyroid function indicators between the two groups. The prevalence of anxiety symptoms in the IFG group was 20.9 %, which was significantly higher than that in the NIFG group (10.4 %). Furthermore, anxiety symptoms were significantly associated with female, marital status, psychotic symptoms, suicide attempts, and low high-density lipoprotein (HDL-C). Conclusion: FEDN MDD patients with anxiety who have IFG are more likely to have problems with thyroid function, lipid metabolism, psychotic symptoms and suicide attempts, especially in female patients. Prevention of these problems should be enhanced when treating such patients. |
收录类别 | SCI ; SSCI |
WOS关键词 | GENDER-DIFFERENCES ; MENTAL-HEALTH ; SYMPTOMS ; RISK ; DYSLIPIDEMIA ; POPULATION ; EPISODE ; DISEASE ; ADULTS ; SCALE |
资助项目 | National Key Research and Devel-opment Program of China[2017YFC1310400] ; provincial Natural Science Foundation of Hunan Province[2020JJ4795] ; Hunan Provincial Innovation Foundation for Postgraduate[CX20220341] ; Fundamental Research Founds for the Central Universities of Central South University[2022ZZTS0259] |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:000920752000001 |
资助机构 | National Key Research and Devel-opment Program of China ; provincial Natural Science Foundation of Hunan Province ; Hunan Provincial Innovation Foundation for Postgraduate ; Fundamental Research Founds for the Central Universities of Central South University |
源URL | [http://ir.psych.ac.cn/handle/311026/44617] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Liu, Tieqiao; Zhang, Xiangyang |
作者单位 | 1.Cent South Univ, Dept Psychiat, Xiangya Hosp 2, Changsha, Hunan, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Shandong First Med Univ, Shandong Prov Hosp, Jinan, Shandong, Peoples R China 4.Cent South Univ, Natl Clin Res Ctr Mental Disorders, Xiangya Hosp 2, Changsha, Hunan, Peoples R China 5.Cent South Univ, Dept Psychiat, Changsha, Hunan, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Qianjin,Li, Yifan,Ren, Honghong,et al. Metabolic characteristics, prevalence of anxiety and its influencing factors in first-episode and drug-na?ve major depressive disorder patients with impaired fasting glucose[J]. JOURNAL OF AFFECTIVE DISORDERS,2023,324:341-348. |
APA | Wang, Qianjin.,Li, Yifan.,Ren, Honghong.,Huang, Qiuping.,Wang, Xuyi.,...&Zhang, Xiangyang.(2023).Metabolic characteristics, prevalence of anxiety and its influencing factors in first-episode and drug-na?ve major depressive disorder patients with impaired fasting glucose.JOURNAL OF AFFECTIVE DISORDERS,324,341-348. |
MLA | Wang, Qianjin,et al."Metabolic characteristics, prevalence of anxiety and its influencing factors in first-episode and drug-na?ve major depressive disorder patients with impaired fasting glucose".JOURNAL OF AFFECTIVE DISORDERS 324(2023):341-348. |
入库方式: OAI收割
来源:心理研究所
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