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A molecular probe carrying anti-tropomyosin 4 for early diagnosis of cerebral ischemia/reperfusion injury

文献类型：期刊论文

作者Yu, Teng-Fei5; Wang, Kun4; Yin, Lu5; Li, Wen-Zhe3; Li, Chuan-Ping2; Zhang, Wei5; Tian, Jie1,4; He, Wen5
刊名NEURAL REGENERATION RESEARCH
出版日期2023-06-01
卷号18期号:6页码:1321-1324
ISSN号1673-5374
关键词cerebral ischemia/reperfusion injury diagnosis dynamic monitoring ischemic stroke middle cerebral artery occlusion molecular probe nanoshells photoacoustic imaging tropomyosin 4 ultrasound
DOI10.4103/1673-5374.357907
通讯作者Tian, Jie(jie.tian@ia.ac.cn) ; He, Wen(hewen@bjtth.org)
英文摘要In vivo imaging of cerebral ischemia/reperfusion injury remains an important challenge. We injected porous Ag/Au@SiO2 bimetallic hollow nanoshells carrying anti-tropomyosin 4 as a molecular probe into mice with cerebral ischemia/reperfusion injury and observed microvascular changes in the brain using photoacoustic imaging with ultrasonography. At each measured time point, the total photoacoustic signal was significantly higher on the affected side than on the healthy side. Twelve hours after reperfusion, cerebral perfusion on the affected side increased, cerebrovascular injury worsened, and anti-tropomyosin 4 expression increased. Twenty-four hours after reperfusion and later, perfusion on the affected side declined slowly and stabilized after 1 week; brain injury was also alleviated. Histopathological and immunohistochemical examinations confirmed the brain injury tissue changes. The nanoshell molecular probe carrying anti-tropomyosin 4 has potential for use in early diagnosis of cerebral ischemia/reperfusion injury and evaluating its progression.
WOS关键词LIVING SUBJECTS ; TOMOGRAPHY ; EXPRESSION ; ISCHEMIA
资助项目National Natural Science Foundation of China[81730050]
WOS研究方向Cell Biology ; Neurosciences & Neurology
语种英语
出版者WOLTERS KLUWER MEDKNOW PUBLICATIONS
WOS记录号WOS:000894528300029
资助机构National Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/51009]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Tian, Jie; He, Wen
作者单位1.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Engn Med, Beijing, Peoples R China
2.Anhui Polytech Univ, Sch Chem & Environm Engn, Anhui Prov Key Lab Funct Coordinated Complexes Mat, Wuhu, Anhui Province, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China
5.Capital Med Univ, Beijing Tiantan Hosp, Dept Ultrasound, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Teng-Fei,Wang, Kun,Yin, Lu,et al. A molecular probe carrying anti-tropomyosin 4 for early diagnosis of cerebral ischemia/reperfusion injury[J]. NEURAL REGENERATION RESEARCH,2023,18(6):1321-1324.
APA Yu, Teng-Fei.,Wang, Kun.,Yin, Lu.,Li, Wen-Zhe.,Li, Chuan-Ping.,...&He, Wen.(2023).A molecular probe carrying anti-tropomyosin 4 for early diagnosis of cerebral ischemia/reperfusion injury.NEURAL REGENERATION RESEARCH,18(6),1321-1324.
MLA Yu, Teng-Fei,et al."A molecular probe carrying anti-tropomyosin 4 for early diagnosis of cerebral ischemia/reperfusion injury".NEURAL REGENERATION RESEARCH 18.6(2023):1321-1324.

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来源：自动化研究所

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