Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment
文献类型:期刊论文
作者 | Wang, Qian6,7; Wang, Zihua5; Li, Zhangfu3,4; Li, Dan2; He, Fangfei1; Wang, Kun6; Tian, Jie6; Zhao, Xinming7 |
刊名 | NANO TODAY |
出版日期 | 2023-02-01 |
卷号 | 48页码:11 |
ISSN号 | 1748-0132 |
关键词 | Pancreatic cancer MFOLFIRINOX regimen Cell membrane biomimetic platform Drug delivery Multimodal visualization |
DOI | 10.1016/j.nantod.2022.101733 |
通讯作者 | Wang, Zihua(wangzh@fjmu.edu.cn) ; Wang, Kun(kun.wang@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Zhao, Xinming(xinmingzh2017@yeah.net) |
英文摘要 | The most effective treatment of pancreatic cancer (PC) is known as mFOLFIRINOX scheme. However, this regimen has relatively severe toxic effects and are commonly restricted to patients with sound physique, which is poor in drug-selectivity, non-specific causing serious toxicity, greatly limits clinical application. Safer and more effective strategy seamlessly and synchronously is needed as advanced treatments for pancreatic cancer in future. In this report, we exploit a biomimetic nanoparticle-based platform for optimizing mFOL-FIRINOX regimen. By coating pancreatic cancer cell membrane (PCCM) onto the surface of polymeric cores that loaded with mFOLFIRINOX, we prepare PCCM-cloaked nanoparticles, namely CNP@folfirinox, which inherit the antigenic exterior structure and associated functions of PC cells. The resulting CNP@folfirinox displays a core-shell nanostructure, which consisting of polymeric core and cancer cell membrane shell with suitable size and surface charge. Particularly, owing to inheriting the inherent membrane protein expressions profile, CNP@folfirinox exhibits prominent advantages in homologous homing to tumor tissue and deep penetration. It also shows lower side effects compared to extensive mFOLFIRINOX i.v. administration with no appreciable toxicity in other organs outside the tumor in vivo. Meanwhile, CNP@folfirinox is endowed with the "Don't eat me" privilege, hard for the immune system to recognize and less reticuloendothelial system uptake, with prolonged blood circulation, therefore improving delivery efficiency of drug after intravenous administration. Thus, this work reshapes a promising paradigm for more safe and more effective mFOLFIR-INOX strategy for further clinical pancreatic cancer treatment. (c) 2022 Elsevier Ltd. All rights reserved. |
WOS关键词 | DRUG-DELIVERY ; TOLERABILITY ; COMBINATION ; EFFICACY |
资助项目 | Ministry of Science and Technology of China[2017YFA0205200] ; National Natural Science Foundation of China[81901813] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[92159305] ; CAMS Innovation Fund for Medical Science[2021-I2M-CT-B-067] ; Joint Funds for the Innovation of Science and Technology Fujian Province[2019Y9001] |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000911494900001 |
资助机构 | Ministry of Science and Technology of China ; National Natural Science Foundation of China ; CAMS Innovation Fund for Medical Science ; Joint Funds for the Innovation of Science and Technology Fujian Province |
源URL | [http://ir.ia.ac.cn/handle/173211/51054] |
专题 | 自动化研究所_中国科学院分子影像重点实验室 |
通讯作者 | Wang, Zihua; Wang, Kun; Tian, Jie; Zhao, Xinming |
作者单位 | 1.Natl Ctr Nanosci & Technol NCNST, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat Nanosafety, Beijing 100190, Peoples R China 2.Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, State Key Lab Mol Oncol, Beijing 100021, Peoples R China 3.Technol Med Ctr, Guangzhou 518036, Peoples R China 4.Hong Kong Univ Sci, Shenzhen Peking Univ, Shenzhen Hosp, Dept Hepatopancreato Biliary Surg, Guangzhou 518036, Peoples R China 5.Fujian Med Univ, Sch Basic Med Sci, Fujian Prov Key Lab Brain Aging & Neurodegenerat D, Fuzhou 350122, Fujian, Peoples R China 6.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 7.Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Dept Diagnost Imaging, Beijing 100021, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Qian,Wang, Zihua,Li, Zhangfu,et al. Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment[J]. NANO TODAY,2023,48:11. |
APA | Wang, Qian.,Wang, Zihua.,Li, Zhangfu.,Li, Dan.,He, Fangfei.,...&Zhao, Xinming.(2023).Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment.NANO TODAY,48,11. |
MLA | Wang, Qian,et al."Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment".NANO TODAY 48(2023):11. |
入库方式: OAI收割
来源:自动化研究所
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