Chitosan Oligosaccharides Regulate the Occurrence and Development of Enteritis in a Human Gut-On-a-Chip
文献类型：期刊论文
| 作者 | Jing, Bolin1,2; Xia, Kun3; Zhang, Chen1; Jiao, Siming1; Zhu, Limeng1; Wei, Jinhua1; Wang, Zhuo A.1; Chen, Nannan4; Tu, Pengfei2; Li, Jianjun1 |
| 刊名 | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
 |
| 出版日期 | 2022-04-26 |
| 卷号 | 10页码:10 |
| 关键词 | chitosan oligosaccharides human gut-on-a-chip enteritis mucous layer E coli |
| ISSN号 | 2296-634X |
| DOI | 10.3389/fcell.2022.877892 |
| 英文摘要 | Past studies on the protective effects of chitosan oligosaccharides (COS) on inflammatory bowel disease (IBD) commonly rely on animal models, because traditional cell culture systems couldn't faithfully mimic human intestinal physiology. Here a novel human gut-on-a-chip microsystem was established to further explore the regulatory effects of COS on the occurrence and development of human enteritis. By constructing an intestinal injury model caused by dextran sodium sulfate (DSS) on the chip, this study proved that COS can reduce intestinal epithelial injury by promoting the expression of the mucous layer for the first time. By establishing an inflammatory bowel disease model on the chip caused by E. coli 11775, this study demonstrated that COS can protect the intestinal epithelial barrier and vascular endothelial barrier by inhibiting the adhesion and invasion of E. coli 11775 for the first time. In addition, similar to the results in vivo, COS can decrease the inflammatory response by reducing the expression of toll-like receptor 4 protein and reducing the nuclear DNA binding rate of nuclear factor kappa-B protein on this chip. In summary, COS can be used as a potential drug to treat human IBD and the human gut-on-a-chip would be used as a platform for quick screening drugs to treat human IBD in future. |
| WOS关键词 | INFLAMMATORY-BOWEL-DISEASE ; HOMEOSTASIS ; MICROBIOTA ; METASTASIS ; MECHANISMS |
| 资助项目 | National Key R&D Program of China[2019YFC1605203] ; National Natural Science Foundation of China[31870802] |
| WOS研究方向 | Cell Biology ; Developmental Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000795028700001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/53268]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Tu, Pengfei; Li, Jianjun; Du, Yuguang |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China 2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China 3.Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Hengyang, Peoples R China 4.China Food Ind Promot Ctr, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jing, Bolin,Xia, Kun,Zhang, Chen,et al. Chitosan Oligosaccharides Regulate the Occurrence and Development of Enteritis in a Human Gut-On-a-Chip[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2022,10:10. |
| APA | Jing, Bolin.,Xia, Kun.,Zhang, Chen.,Jiao, Siming.,Zhu, Limeng.,...&Du, Yuguang.(2022).Chitosan Oligosaccharides Regulate the Occurrence and Development of Enteritis in a Human Gut-On-a-Chip.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,10,10. |
| MLA | Jing, Bolin,et al."Chitosan Oligosaccharides Regulate the Occurrence and Development of Enteritis in a Human Gut-On-a-Chip".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10(2022):10. |
入库方式： OAI收割
来源：过程工程研究所
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