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Imaging Intracellular Drug/siRNA Co-Delivery by Self-Assembly Cross-Linked Polyethylenimine with Fluorescent Core-Shell Silica Nanoparticles

文献类型：期刊论文

作者Zhang, Ruirui1,2,3; Wei, Shuang1; Shao, Leihou3; Tong, Lili2; Wu, Yan3
刊名POLYMERS
出版日期2022-05-01
卷号14期号:9页码:12
关键词mesoporous silica disulfide cross-linked PEI imaging fluorescence
DOI10.3390/polym14091813
英文摘要Multifunctional theranostic nanomaterial represents one type of emerging agent with the potential to offer both sensitive diagnosis and effective therapy. Herein, we report a novel drug/siRNA co-delivery nanocarrier, which is based on fluorescent mesoporous core-shell silica nanoparticles coated by cross-linked polyethylenimine. The fluorescent mesoporous core-shell silica nanoparticles can provide numerous pores for drug loading and negative charged surface to assemble cross-linked polyethylenimine via electrostatic interaction. Disulfide cross-linked polyethylenimine can be absorbed on the surface of silica nanoparticles which provide the feasibility to bind with negatively charged siRNA and release drug "on-demand". In addition, the hybrid nanoparticles can be easily internalized into cells to realize drug/siRNA co-delivery and therapeutic effect imaging. This work would stimulate interest in the use of self-assembled cross-linked polyethylenimine with fluorescent mesoporous core-shell silica nanoparticles to construct multifunctional nanocomposites for tumor therapy.
WOS关键词DRUG-DELIVERY ; QUANTUM DOTS ; CARBON DOTS ; RELEASE ; NANOCARRIERS ; AGGREGATION ; NANOSHEETS ; EMISSION ; CHARGE ; SIZE
资助项目National Natural Science Foundation of China[22078338] ; National Natural Science Foundation of China[81773185] ; Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals[2019FCCEKL07] ; open foundation of Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University[2018KLMNP06]
WOS研究方向Polymer Science
语种英语
WOS记录号WOS:000795384300001
出版者MDPI
资助机构National Natural Science Foundation of China ; Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals ; open foundation of Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University
源URL[http://ir.ipe.ac.cn/handle/122111/53316]  
专题中国科学院过程工程研究所
通讯作者Wu, Yan
作者单位1.Chinese Acad Sci, Beijing Key Lab Ion Liquids Clean Proc, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
2.Shandong Normal Univ, Coll Chem, Key Lab Mol & Nano Probes, Shandong Prov Key Lab Clean Prod Fine Chem, Jinan 250014, Peoples R China
3.CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Ruirui,Wei, Shuang,Shao, Leihou,et al. Imaging Intracellular Drug/siRNA Co-Delivery by Self-Assembly Cross-Linked Polyethylenimine with Fluorescent Core-Shell Silica Nanoparticles[J]. POLYMERS,2022,14(9):12.
APA Zhang, Ruirui,Wei, Shuang,Shao, Leihou,Tong, Lili,&Wu, Yan.(2022).Imaging Intracellular Drug/siRNA Co-Delivery by Self-Assembly Cross-Linked Polyethylenimine with Fluorescent Core-Shell Silica Nanoparticles.POLYMERS,14(9),12.
MLA Zhang, Ruirui,et al."Imaging Intracellular Drug/siRNA Co-Delivery by Self-Assembly Cross-Linked Polyethylenimine with Fluorescent Core-Shell Silica Nanoparticles".POLYMERS 14.9(2022):12.

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来源：过程工程研究所

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