Oil-in-ionic liquid nanoemulsion-based intranasal delivery system for influenza split-virus vaccine
文献类型：期刊论文
| 作者 | Lin, Xuan1; Sheng, Yanan1,2; Zhang, Xuan1; Li, Zhengjun1; Yang, Yanli1; Wu, Jie; Su, Zhiguo; Ma, Guanghui; Zhang, Songping1 |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2022-06-01 |
| 卷号 | 346页码:380-391 |
| ISSN号 | 0168-3659 |
| 关键词 | Ionic liquids Adjuvant Nanoemulsion Intranasal immune Vaccine delivery system Influenza |
| DOI | 10.1016/j.jconrel.2022.04.036 |
| 英文摘要 | Effective antigen delivery and immune stimulation in nasal mucosa determine the success of mucosal immunity. Here, an oil-in-ionic liquid (o/IL) nanoemulsion formulated with choline and niacin IL ([Cho][Nic]), squalene, and Tween 80 surfactant is explored as a vaccine delivery system for intranasal mucosal immunization. Compared to the o/w emulsion counterpart without the ILs, the o/IL manoemulsion showed a reduced and more uniform size of approximately 168 nm and significantly improved stability. Studies in mice model showed that when was used as an intranasal vaccine delivery system for influenza split-virus antigens, the antigens in the o/IL nanoemulsion induced strong mucosal immune responses with secretory IgA titers 25- and 5.8-fold higher than those of naked and commercial MF59-adjuvanted antigens, respectively. The o/IL nanoemulsion system also induced stronger systemic humoral responses. The excellent mucosal adjuvant effects of the o/IL nanoemulsion mainly benefited from the prolonged retention of antigens in the nasal cavity, enhanced antigen permeation into the submucosa, and the consequently promoted proliferation of CD11b cells and CD4+ T cells in nasal mucosaassociated lymphoid tissue. Moreover, when used as an injection adjuvant, the o/IL nanoemulsion also induced stronger humoral immune responses than MF59. Thus, the [Cho][Nic]-based o/IL nanoemulsion vaccine delivery system can serve as a promising adjuvant platform. |
| WOS关键词 | MUCOSAL IMMUNITY ; ADJUVANTS ; RESPONSES |
| 资助项目 | National Natural Science Foundation of China[31970872] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[21808226] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000800217600001 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/53502]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zhang, Songping |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Xuan,Sheng, Yanan,Zhang, Xuan,et al. Oil-in-ionic liquid nanoemulsion-based intranasal delivery system for influenza split-virus vaccine[J]. JOURNAL OF CONTROLLED RELEASE,2022,346:380-391. |
| APA | Lin, Xuan.,Sheng, Yanan.,Zhang, Xuan.,Li, Zhengjun.,Yang, Yanli.,...&Zhang, Songping.(2022).Oil-in-ionic liquid nanoemulsion-based intranasal delivery system for influenza split-virus vaccine.JOURNAL OF CONTROLLED RELEASE,346,380-391. |
| MLA | Lin, Xuan,et al."Oil-in-ionic liquid nanoemulsion-based intranasal delivery system for influenza split-virus vaccine".JOURNAL OF CONTROLLED RELEASE 346(2022):380-391. |
入库方式： OAI收割
来源：过程工程研究所
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