Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation
文献类型:期刊论文
作者 | Li, Liteng2; Li, Xiaofang2; Zhang, Susu2; Yan, Hongyuan2; Qiao, Xiaoqiang2; He, Hongyan1; Zhu, Tao2; Tang, Baokun2 |
刊名 | GREEN ENERGY & ENVIRONMENT
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出版日期 | 2022-08-01 |
卷号 | 7期号:4页码:840-853 |
关键词 | Greenness Deep eutectic solvent Polymer Toxicity Application |
ISSN号 | 2096-2797 |
DOI | 10.1016/j.gee.2021.02.006 |
英文摘要 | Acrylic acid (AA) is an important and widely used industrial chemical, but its high toxicity renders its use incompatible with the concept of green development. By leveraging its terminal carboxyl group and unsaturated bond, we designed and explored a new strategy to increase the greenness of AA via its eutectic melting using a quaternary ammonium salt (choline chloride) to form a deep eutectic solvent (DES), followed by polymerisation of the DES to form a polymer (poly(DES)). The greenness of AA, DES, and poly(DES) was evaluated via an in vitro test using MGC80-3 cells and an in vivo test using Kunming mice. The toxicity improved from Grade 2 (moderately toxic) for AA to Grade 1 (slightly toxic) for DESs and Grade 0 (non-toxic) for poly(DES) in the in vitro test. Moreover, the poly(DES)s showed a lower toxicity in mice than the DESs in the in vivo test. Thus, greenness enhancement was successfully achieved, with the greenness following the order AA < DES < poly(DES). Furthermore, the mechanisms underlying the change in toxicity were explored through microscopy and flow cytometry, which revealed that the DES can permeate the MGC80-3 cell membrane during the G(0)/G(1) phase to adversely affect DNA synthesis in the S phase, but the poly(DES) cannot. Finally, the green poly(DES), which showed good adsorption properties and flexible functionality, was successfully applied as a carrier or excipient of drugs. Through the novel strategy reported herein, greenness enhancement and the broadening of the application scope of a toxic organic acid were achieved, making such acids applicable for green development. (C) 2021 Institute of Process Engineering, Chinese Academy of Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. |
WOS关键词 | CHOLINE CHLORIDE ; IN-VITRO ; IONIC LIQUIDS ; ACRYLIC-ACID ; SOLVENTS ; TOXICITY ; POLYMERS ; NANOPARTICLES ; OXIDATION ; CATALYSTS |
资助项目 | National Natural Science Foundation of China[22178081] ; Interdisciplinary Research Program of Natural Science of Hebei University[DXK202116] ; Functional Pharmaceutical Chromatographic Materials Innovation Team[605020521006] ; High-level Talents Introduction Program of Hebei University |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Energy & Fuels ; Engineering |
语种 | 英语 |
WOS记录号 | WOS:000802945400004 |
出版者 | KEAI PUBLISHING LTD |
资助机构 | National Natural Science Foundation of China ; Interdisciplinary Research Program of Natural Science of Hebei University ; Functional Pharmaceutical Chromatographic Materials Innovation Team ; High-level Talents Introduction Program of Hebei University |
源URL | [http://ir.ipe.ac.cn/handle/122111/53645] ![]() |
专题 | 中国科学院过程工程研究所 |
通讯作者 | He, Hongyan; Zhu, Tao; Tang, Baokun |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 010190, Peoples R China 2.Hebei Univ, Coll Pharmaceut Sci, Inst Life Sci & Green Dev, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Liteng,Li, Xiaofang,Zhang, Susu,et al. Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation[J]. GREEN ENERGY & ENVIRONMENT,2022,7(4):840-853. |
APA | Li, Liteng.,Li, Xiaofang.,Zhang, Susu.,Yan, Hongyuan.,Qiao, Xiaoqiang.,...&Tang, Baokun.(2022).Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation.GREEN ENERGY & ENVIRONMENT,7(4),840-853. |
MLA | Li, Liteng,et al."Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation".GREEN ENERGY & ENVIRONMENT 7.4(2022):840-853. |
入库方式: OAI收割
来源:过程工程研究所
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