中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation

文献类型:期刊论文

作者Li, Liteng2; Li, Xiaofang2; Zhang, Susu2; Yan, Hongyuan2; Qiao, Xiaoqiang2; He, Hongyan1; Zhu, Tao2; Tang, Baokun2
刊名GREEN ENERGY & ENVIRONMENT
出版日期2022-08-01
卷号7期号:4页码:840-853
关键词Greenness Deep eutectic solvent Polymer Toxicity Application
ISSN号2096-2797
DOI10.1016/j.gee.2021.02.006
英文摘要Acrylic acid (AA) is an important and widely used industrial chemical, but its high toxicity renders its use incompatible with the concept of green development. By leveraging its terminal carboxyl group and unsaturated bond, we designed and explored a new strategy to increase the greenness of AA via its eutectic melting using a quaternary ammonium salt (choline chloride) to form a deep eutectic solvent (DES), followed by polymerisation of the DES to form a polymer (poly(DES)). The greenness of AA, DES, and poly(DES) was evaluated via an in vitro test using MGC80-3 cells and an in vivo test using Kunming mice. The toxicity improved from Grade 2 (moderately toxic) for AA to Grade 1 (slightly toxic) for DESs and Grade 0 (non-toxic) for poly(DES) in the in vitro test. Moreover, the poly(DES)s showed a lower toxicity in mice than the DESs in the in vivo test. Thus, greenness enhancement was successfully achieved, with the greenness following the order AA < DES < poly(DES). Furthermore, the mechanisms underlying the change in toxicity were explored through microscopy and flow cytometry, which revealed that the DES can permeate the MGC80-3 cell membrane during the G(0)/G(1) phase to adversely affect DNA synthesis in the S phase, but the poly(DES) cannot. Finally, the green poly(DES), which showed good adsorption properties and flexible functionality, was successfully applied as a carrier or excipient of drugs. Through the novel strategy reported herein, greenness enhancement and the broadening of the application scope of a toxic organic acid were achieved, making such acids applicable for green development. (C) 2021 Institute of Process Engineering, Chinese Academy of Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
WOS关键词CHOLINE CHLORIDE ; IN-VITRO ; IONIC LIQUIDS ; ACRYLIC-ACID ; SOLVENTS ; TOXICITY ; POLYMERS ; NANOPARTICLES ; OXIDATION ; CATALYSTS
资助项目National Natural Science Foundation of China[22178081] ; Interdisciplinary Research Program of Natural Science of Hebei University[DXK202116] ; Functional Pharmaceutical Chromatographic Materials Innovation Team[605020521006] ; High-level Talents Introduction Program of Hebei University
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Energy & Fuels ; Engineering
语种英语
WOS记录号WOS:000802945400004
出版者KEAI PUBLISHING LTD
资助机构National Natural Science Foundation of China ; Interdisciplinary Research Program of Natural Science of Hebei University ; Functional Pharmaceutical Chromatographic Materials Innovation Team ; High-level Talents Introduction Program of Hebei University
源URL[http://ir.ipe.ac.cn/handle/122111/53645]  
专题中国科学院过程工程研究所
通讯作者He, Hongyan; Zhu, Tao; Tang, Baokun
作者单位1.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 010190, Peoples R China
2.Hebei Univ, Coll Pharmaceut Sci, Inst Life Sci & Green Dev, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China
推荐引用方式
GB/T 7714
Li, Liteng,Li, Xiaofang,Zhang, Susu,et al. Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation[J]. GREEN ENERGY & ENVIRONMENT,2022,7(4):840-853.
APA Li, Liteng.,Li, Xiaofang.,Zhang, Susu.,Yan, Hongyuan.,Qiao, Xiaoqiang.,...&Tang, Baokun.(2022).Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation.GREEN ENERGY & ENVIRONMENT,7(4),840-853.
MLA Li, Liteng,et al."Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation".GREEN ENERGY & ENVIRONMENT 7.4(2022):840-853.

入库方式: OAI收割

来源:过程工程研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。