中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 过程工程研究所
  3. 中国科学院过程工程研究所
Transformable vesicles for cancer immunotherapy

文献类型：期刊论文

作者Wang, Shuang1; Hu, Xiaoming1,2; Wei, Wei1,2; Ma, Guanghui1,2
刊名ADVANCED DRUG DELIVERY REVIEWS
出版日期2021-12-01
卷号179页码:22
关键词Vesicles Transformation Cancer immunotherapy Stimuli-sensitive Immune activation Tumor microenvironment Immunogenic cell death
ISSN号0169-409X
DOI10.1016/j.addr.2021.113905
英文摘要Immunotherapy that utilizes the human immune system to fight cancer represents a revolutionary method for cancer treatment. Immunotherapeutic agents that trigger the immune response should be carefully delivered to the desired site to maximize immunotherapy effectiveness and minimize side effects. Vesicles offer the possibility of encapsulating both hydrophilic and hydrophobic drugs and thus serve as a promising delivery tool. As multiple irreconcilable requirements exist at different transport stages, developing vesicles transformable in response to given stimuli is of great significance. In this review, we first introduced various vesicle types used for immunotherapy. Furthermore, the typical stimuli that trigger vesicle transformation and the usually generated transformation styles were described. Focusing on three aspects of antigen-presenting cell (APC)/T cell activation, tumor microenvironment (TME) amelioration, and immunogenic cell death (ICD)-induced immunotherapy, we reviewed recently reported transformable vesicles for tumor treatment. Finally, we put forward possible directions for future research and clinical translation. (C) 2021 Elsevier B.V. All rights reserved.
WOS关键词NONIONIC SURFACTANT VESICLES ; IMMUNOGENIC CELL-DEATH ; MATRIX METALLOPROTEINASES MMPS ; ANTIGEN-PRESENTING CELLS ; ADJUVANT-CARRIER SYSTEM ; OUTER-MEMBRANE VESICLES ; LOADED BUBBLE LIPOSOMES ; DRUG-DELIVERY SYSTEMS ; EXTRACELLULAR VESICLES ; DENDRITIC CELLS
资助项目National Natural Science Foundation of China[32030062] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[U2001224] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000806246700003
出版者ELSEVIER
资助机构National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
源URL[http://ir.ipe.ac.cn/handle/122111/53833]  
专题中国科学院过程工程研究所
通讯作者Wei, Wei; Ma, Guanghui
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 Bei Er Tiao, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Shuang,Hu, Xiaoming,Wei, Wei,et al. Transformable vesicles for cancer immunotherapy[J]. ADVANCED DRUG DELIVERY REVIEWS,2021,179:22.
APA Wang, Shuang,Hu, Xiaoming,Wei, Wei,&Ma, Guanghui.(2021).Transformable vesicles for cancer immunotherapy.ADVANCED DRUG DELIVERY REVIEWS,179,22.
MLA Wang, Shuang,et al."Transformable vesicles for cancer immunotherapy".ADVANCED DRUG DELIVERY REVIEWS 179(2021):22.

入库方式： OAI收割

来源：过程工程研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。