Albumin-mediated "Unlocking" of supramolecular prodrug-like nanozymes toward selective imaging-guided phototherapy
文献类型：期刊论文
| 作者 | Han, Jingjing4; Li, Haidong1,4; Zhao, Luyang2; Kim, Gyoungmi4; Chen, Yahui3,4; Yan, Xuehai2,5; Yoon, Juyoung4 |
| 刊名 | CHEMICAL SCIENCE
 |
| 出版日期 | 2022-06-06 |
| 页码 | 7 |
| ISSN号 | 2041-6520 |
| DOI | 10.1039/d2sc02025d |
| 英文摘要 | Construction of an activatable photosensitizer and integration into an adaptive nanozyme during phototherapy without producing off-target toxicity remains a challenge. Herein, we have fabricated a prodrug-like supramolecular nanozyme based on a metallic-curcumin and cyanine co-assembly. The albumin-mediated phenol AOH group transformation of nanozyme changes its adjustable oxygen stress from negative superoxide dismutase-like activity of ROS-scavenging to positive photo oxidase activity with an ROS-amplifying capacity. It further increases the depth penetration of a nanozyme in a tumor spheroid, selectively targeting tumorous phototherapy. It also triggers a signal in targeted tumor cells and helps increase cancer cell ablation. This work suggests new options for development of activatable supramolecular nanozymes and provides a synergetic prodrug-like nanozyme strategy for early diagnosis and preclinical phototherapeutics. |
| WOS关键词 | SUPEROXIDE-DISMUTASE ACTIVITY ; FUNCTIONAL MIMICS ; SINGLET OXYGEN ; SERUM-ALBUMIN ; CURCUMIN ; NANOPARTICLES ; CANCER ; GENERATION ; COMPLEXES ; STRATEGY |
| 资助项目 | National Research Foundation of Korea (NRF) - Korea government (MSIT)[2022R1A2C3005420] ; National Natural Science Foundation of China[22025207] ; National Natural Science Foundation of China[21977095] ; National Natural Science Foundation of China[22077122] ; Fundamental Research Funds for the Central Universities[DUT22RC(3)025] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000811778000001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Research Foundation of Korea (NRF) - Korea government (MSIT) ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/53839]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Yan, Xuehai; Yoon, Juyoung |
| 作者单位 | 1.Dalian Univ Technol, Sch Bioengn, Dalian 116024, Peoples R China 2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 3.Ewha Wamans Univ, New & Renewable Energy Res Ctr, Seoul 03760, South Korea 4.Ewha Wamans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea 5.Chinese Acad Sci, Ctr Mesosci, Inst Proc Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Jingjing,Li, Haidong,Zhao, Luyang,et al. Albumin-mediated "Unlocking" of supramolecular prodrug-like nanozymes toward selective imaging-guided phototherapy[J]. CHEMICAL SCIENCE,2022:7. |
| APA | Han, Jingjing.,Li, Haidong.,Zhao, Luyang.,Kim, Gyoungmi.,Chen, Yahui.,...&Yoon, Juyoung.(2022).Albumin-mediated "Unlocking" of supramolecular prodrug-like nanozymes toward selective imaging-guided phototherapy.CHEMICAL SCIENCE,7. |
| MLA | Han, Jingjing,et al."Albumin-mediated "Unlocking" of supramolecular prodrug-like nanozymes toward selective imaging-guided phototherapy".CHEMICAL SCIENCE (2022):7. |
入库方式： OAI收割
来源：过程工程研究所
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