Advances in encapsulating gonadotropin-releasing hormone agonists for controlled release: a review
文献类型：期刊论文
| 作者 | Bazybek, Nardana1,2; Wei, Yi1,2 ; Ma, Guanghui1,2
|
| 刊名 | JOURNAL OF MICROENCAPSULATION
 |
| 出版日期 | 2022-07-27 |
| 页码 | 15 |
| 关键词 | Microspheres encapsulation efficiency GnRH agonist controlled release release studies |
| ISSN号 | 0265-2048 |
| DOI | 10.1080/02652048.2022.2100934 |
| 英文摘要 | Gonadotropin-releasing hormone (GnRH) agonists are peptides consisting of nine or ten amino acid residues. GnRH agonists have been applied in the therapy of sexual hormone disorders like prostate cancer, endometriosis, uterine myoma, central precious puberty, and in-vitro fertility. Treatment is achieved by continuous hormone intake and long-term agonists administration, which is usually associated with poor patient compliance. Because GnRH agonists that are administered with the parenteral route are broken down by peptidase, their half-life is short. As a result, developing sustained release for the drug delivery system is significant. Even though some drugs have been successfully delivered with long-acting release microspheres and approved by the Food and Drug Administration (FDA), some challenges remain. This review highlighted current approaches to encapsulate GnRH agonists into delivery systems and strategies encountered during the loading process. Moreover, the following sections provide strategies to improve the release profile, and animal and human studies were summarised. |
| WOS关键词 | LEUPROLIDE ACETATE ; PLGA MICROSPHERES ; DRUG-DELIVERY ; CLINICAL PHARMACOKINETICS ; INJECTABLE MICROSPHERES ; POLYMERIC MICROSPHERES ; TESTOSTERONE LEVELS ; FORMULATION ; DEPOT ; MICROPARTICLES |
| 资助项目 | National Key Technology Program[2017ZX09201004013] |
| WOS研究方向 | Chemistry ; Engineering ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000832535100001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 资助机构 | National Key Technology Program |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/54224]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wei, Yi |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bazybek, Nardana,Wei, Yi,Ma, Guanghui. Advances in encapsulating gonadotropin-releasing hormone agonists for controlled release: a review[J]. JOURNAL OF MICROENCAPSULATION,2022:15. |
| APA | Bazybek, Nardana,Wei, Yi,&Ma, Guanghui.(2022).Advances in encapsulating gonadotropin-releasing hormone agonists for controlled release: a review.JOURNAL OF MICROENCAPSULATION,15. |
| MLA | Bazybek, Nardana,et al."Advances in encapsulating gonadotropin-releasing hormone agonists for controlled release: a review".JOURNAL OF MICROENCAPSULATION (2022):15. |
入库方式： OAI收割
来源：过程工程研究所
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