PEG-Functionalized Hollow Multishelled Structures with On-Off Switch and Rate-Regulation for Controllable Antimicrobial Release
文献类型：期刊论文
| 作者 | Zhao, Decai1; Wei, Yanze1; Jin, Quan1; Yang, Nailiang1,2; Yang, Yang3; Wang, Dan1,2 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2022-07-27 |
| 页码 | 7 |
| ISSN号 | 1433-7851 |
| 关键词 | Antimicrobial Controlled Release Hollow Multishelled Structure PEG-Functionalization pH-Responsive |
| DOI | 10.1002/anie.202206807 |
| 英文摘要 | The construction of responsive antimicrobial carriers with multifunctional and controllable release is an attractive but challenging proposition. Recently developed hollow multishelled structures (HoMSs) offers structural advantages, such as easily modifiable surfaces and mutually influenced shells. Herein, we report a novel pH-responsive antimicrobial carrier having hierarchical shells as multilevel responsive bodies using polyethylene glycol (PEG) as a gated regulator. The interaction between PEG-functionalized shells endows them with a pH-responsive switch and rate-regulator capability. These features are present in the form of rapid release of molecules wrapped in the outer shell, and controlled diffusion of antimicrobials stored in the inner shell by electrostatic interaction, resulting in a long-lasting mildew resistance for up to 71 days. The versatility of the hierarchical interactions of HoMSs will inspire the design of promising smart drug carriers. |
| WOS关键词 | POLY(ETHYLENE GLYCOL) ; POLYETHYLENE-GLYCOL ; ADSORPTION ; PH ; OXIDE) |
| 资助项目 | National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[52072369] ; National Natural Science Foundation of China[92163209] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000830728100001 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/54303]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Yang, Nailiang; Yang, Yang; Wang, Dan |
| 作者单位 | 1.Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 10049, Peoples R China 3.Tongji Univ, Shanghai Pulm Hosp, Inst Adv Study, Dept Thorac Surg, Shanghai 200430, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Decai,Wei, Yanze,Jin, Quan,et al. PEG-Functionalized Hollow Multishelled Structures with On-Off Switch and Rate-Regulation for Controllable Antimicrobial Release[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022:7. |
| APA | Zhao, Decai,Wei, Yanze,Jin, Quan,Yang, Nailiang,Yang, Yang,&Wang, Dan.(2022).PEG-Functionalized Hollow Multishelled Structures with On-Off Switch and Rate-Regulation for Controllable Antimicrobial Release.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,7. |
| MLA | Zhao, Decai,et al."PEG-Functionalized Hollow Multishelled Structures with On-Off Switch and Rate-Regulation for Controllable Antimicrobial Release".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022):7. |
入库方式： OAI收割
来源：过程工程研究所
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