PEGylated 2D-nanomaterials alleviate Parkinson's disease by shielding PIP2 lipids to inhibit IP3 second messenger signaling
文献类型：期刊论文
| 作者 | Huang, Liwen1; Zhang, Xiao2; Ding, Zhaowen2; Qi, Yilin1; Wang, Wenjing1; Xu, Xihan1; Yue, Hua2; Bai, Lihuan1; Wang, Heping1; Feng, Leyan1 |
| 刊名 | NANO TODAY
 |
| 出版日期 | 2022-10-01 |
| 卷号 | 46页码:12 |
| ISSN号 | 1748-0132 |
| 关键词 | Two-dimensional nanomaterials Parkinson's disease Nano-bio interface Phosphatidylinositol-4,5-bisphosphate Signaling transduction |
| DOI | 10.1016/j.nantod.2022.101556 |
| 英文摘要 | Researches on nano-bio interfaces have revealed that two-dimensional (2D) nanomaterials can form functionally impactful architectures upon interaction with biological membranes. These biological impacts may drive various changes of membrane phospholipids, raising the possibility of alleviating neurodegenerative disorders by specifically altering metabolism of membrane phospholipids. Here, we demonstrate that PEGylated 2D nanomaterials including graphene oxide and poly -L-lactic acid sheets (denoted as P-sheet) alleviate behavioral and neuronal degeneration of Parkinson's disease (PD). Upon this finding, we experimentally identify enrichment for the phosphatidylinositol-4,5-bisphosphate (PIP2) lipid interacting with P-sheet and reveal the underlying mechanism by molecular dynamics simulations: a flip-flop orientation shift of PIP2 lipids within the membrane restricts the hydrolysis site, preventing cleavage-mediated inositol 1,4,5-trisphosphate. As a result, Ca2+-related endoplasmic reticulum stress can be reduced to protect the neurons of PD mice. These results together support P-sheet nanomaterials as a new type of drug-free agent for selective modulation of neurodegenerative-disorder-associated membrane-lipid dysregulation and potential PD therapy. (C) 2022 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ALPHA-SYNUCLEIN ; MOUSE MODEL ; NANOPARTICLES ; NANOMATERIALS ; DEPRESSION ; NANOSHEETS ; CHEMISTRY ; MEDICINE ; INSIGHTS ; ANXIETY |
| 资助项目 | National Natural Science Foundation of China[31922045] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[32030062] ; National Natural Science Foundation of China[31771031] ; National Natural Science Foundation of China[U2001224] ; National Key Technologies R&D Program of China[2018YFA0209800] ; Open Funding Project of the State Key Laboratory of Biochemical Engineering[2021KF- 01] ; State Key Laboratory of Medicinal Chemical Biology in Nankai University[2020017] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000835033400002 |
| 资助机构 | National Natural Science Foundation of China ; National Key Technologies R&D Program of China ; Open Funding Project of the State Key Laboratory of Biochemical Engineering ; State Key Laboratory of Medicinal Chemical Biology in Nankai University |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/54402]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Ma, Guanghui; Wei, Wei; Xue, Xue |
| 作者单位 | 1.Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Liwen,Zhang, Xiao,Ding, Zhaowen,et al. PEGylated 2D-nanomaterials alleviate Parkinson's disease by shielding PIP2 lipids to inhibit IP3 second messenger signaling[J]. NANO TODAY,2022,46:12. |
| APA | Huang, Liwen.,Zhang, Xiao.,Ding, Zhaowen.,Qi, Yilin.,Wang, Wenjing.,...&Xue, Xue.(2022).PEGylated 2D-nanomaterials alleviate Parkinson's disease by shielding PIP2 lipids to inhibit IP3 second messenger signaling.NANO TODAY,46,12. |
| MLA | Huang, Liwen,et al."PEGylated 2D-nanomaterials alleviate Parkinson's disease by shielding PIP2 lipids to inhibit IP3 second messenger signaling".NANO TODAY 46(2022):12. |
入库方式： OAI收割
来源：过程工程研究所
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