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Efficient Immunotherapy of Drug-Free Layered Double Hydroxide Nanoparticles via Neutralizing Excess Acid and Blocking Tumor Cell Autophagy

文献类型：期刊论文

作者Zhang, Lingxiao1,2,4,5; Jia, Yingbo2,3; Yang, Jinju2; Zhang, Lun2; Hou, Shengjie2,3; Niu, Xiaoyun2; Zhu, Jie2; Huang, Yaru2,3; Sun, Xiaoying2,3; Xu, Zhi Ping1
刊名ACS NANO
出版日期2022-08-23
卷号16期号:8页码:12036-12048
ISSN号1936-0851
关键词layered double hydroxide nanoparticles tumor immune microenvironment acidosis tumor cell apoptosis cancer immunotherapy
DOI10.1021/acsnano.2c02183
英文摘要Cancer immunotherapy efficacy is largely limited by the suppressive tumor immune microenvironment (TIME) where antitumor immune cells are inhibited and tumor antigens continue to mutate or be lost. To remodel the TIME, we here applied weakly alkaline layered double hydroxide nanoparticles (LDH NPs) to neutralize the excess acid and block autophagy of tumor cells for neoadjuvant cancer immunotherapy. Peritumoral injection of LDH NPs provided a long-term and efficient acid-neutralization in the TIME, blocked the lysosome-mediated autophagy pathway in tumor cells, and increased the levels of antitumor tumor-associated macrophages and T cells. These LDH NPs captured tumor antigens released in the tumor tissues and effectively inhibited the growth of both melanoma and colon tumors in vivo. These findings indicate that LDH NPs, as an immunomodulator and adjuvant, successfully "awaken" and promote the host innate and adaptive immune systems, showing promising potential for solid tumor immunotherapy.
WOS关键词CANCER ; INHIBITION ; GLUCOSE ; PH
资助项目National Natural Science Foundation of China[82150107] ; National Natural Science Foundation of China[32101123] ; Ningbo Yongjiang Talent Introduction Program[(2021A -010-G)] ; China Postdoctoral Science Founda- tion[2021M702816] ; Natural Science Foundation of Ningbo[2021J320] ; Australian Research Council Discovery Project[DP190103486]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000841745300001
资助机构National Natural Science Foundation of China ; Ningbo Yongjiang Talent Introduction Program ; China Postdoctoral Science Founda- tion ; Natural Science Foundation of Ningbo ; Australian Research Council Discovery Project
源URL[http://ir.ipe.ac.cn/handle/122111/54462]  
专题中国科学院过程工程研究所
通讯作者Zhang, Lingxiao; Jia, Yingbo; Xu, Zhi Ping; Liu, Ruitian
作者单位1.Univ Queensland, Australian Inst Bioengn & Nanotechnol, St Lucia, Qld 4072, Australia
2.Inst Proc Engn, Chinese Acad Sci, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
4.Zhejiang Univ City Coll, Dept Pharmacol, Sch Med, Hangzhou 310015, Peoples R China
5.Univ Chinese Acad Sci, Ningbo Hwa Mei Hosp, Ningbo Clin Res Ctr Digest Syst Tumors, Key Lab Diag & Treatment Digest Syst Tumors Zhejia, Ningbo 315010, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Lingxiao,Jia, Yingbo,Yang, Jinju,et al. Efficient Immunotherapy of Drug-Free Layered Double Hydroxide Nanoparticles via Neutralizing Excess Acid and Blocking Tumor Cell Autophagy[J]. ACS NANO,2022,16(8):12036-12048.
APA Zhang, Lingxiao.,Jia, Yingbo.,Yang, Jinju.,Zhang, Lun.,Hou, Shengjie.,...&Liu, Ruitian.(2022).Efficient Immunotherapy of Drug-Free Layered Double Hydroxide Nanoparticles via Neutralizing Excess Acid and Blocking Tumor Cell Autophagy.ACS NANO,16(8),12036-12048.
MLA Zhang, Lingxiao,et al."Efficient Immunotherapy of Drug-Free Layered Double Hydroxide Nanoparticles via Neutralizing Excess Acid and Blocking Tumor Cell Autophagy".ACS NANO 16.8(2022):12036-12048.

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来源：过程工程研究所

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