Robust Electrochemical Sensors for Detection of Isoprenaline Using Hexagonal Co3O4 Nanoplates Embedded in Few-Layer Ti3C2Tx Nanosheets
文献类型：期刊论文
| 作者 | Kumar, Jai3; Neiber, Rana R.2,3; Nafady, Ayman4; Albaqami, Munirah D.4; Soomro, Razium Ali1; Baraka, Marwa5; Ahmed, Nazeer6; Karakus, Selcan5 |
| 刊名 | ACS APPLIED NANO MATERIALS
 |
| 出版日期 | 2022-08-26 |
| 卷号 | 5期号:8页码:11352-11360 |
| 关键词 | MXenes isoprenaline hybrid system important therapeutic Co3O4 nanoplates electrochemical sensors hybrid composites |
| DOI | 10.1021/acsanm.2c02445 |
| 英文摘要 | Metal oxide-based electrochemical sensors, despite their robust redox activity, lack sufficient conductivity to overcome their sluggish kinetics. Herein, we propose a unique self-assembled hybrid configuration based on redox-active Co3O4 hexagons (Co3O4-HX) and the highly conductive, few-layer-thick Ti3C2Tx sheets. The self-assembly approach enabled the compact interfacial formation and moderate intercalation of Ti3C2Tx sheets, allowing the Co3O4/Ti3C2Tx composite (Co3O4-MX) to exhibit a synergetic improvement in the charge-transfer rate and oxidation current response toward isoprenaline (ISPT), a neurotransmitter drug. The hybrid composite when devised as an electrochemical sensor gives rise to a 7.9-fold higher oxidation current response to 0.65 mu M ISPT than its pristine Co3O4 counterpart. The improved charge kinetics and generation of a superior oxidation current emphasized the critical role of Ti(3)C(2)T(x )as an interactive substrate in the Co3O4-MX hybrid. The analytical detection capability assessed via differential pulse voltammetry (DPV) confirmed the sensor's high selectivity and marked stability both in low and high concentration ranges of ISPT ((0.01 to 0.33 mu M) and 0.5 to 0.9 mu M) with a limit of detection (LOD) of 3 x 10(-3) mu M (for low concentrations). Importantly, the fabricated sensor could detect ISPT from harsh biological environments such as human urine samples with a recovery rate of 99%. Moreover, the sensor exhibited a stable working response during its prolonged storage of 30 days in an aqueous PBS system. The proposed route of using MXenes as a conductive substrate paves the way for developing a robust metal-oxide-based redox-active hybrid system for the sensitive detection of important therapeutic compounds. |
| 资助项目 | King Saud University, Riyadh, Saudi Arabia[RSP-2022/79] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000849141200001 |
| 资助机构 | King Saud University, Riyadh, Saudi Arabia |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/54536]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Soomro, Razium Ali |
| 作者单位 | 1.Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing Key Lab Electrochem Proc & Technol Mat, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Beijing Key Lab Ion Liquids Clean Proc, CAS Key Lab Green, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Coll Chem Engn, Beijing 100049, Peoples R China 4.King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia 5.Alexandria Univ, Fac Dent, Alexandria, Egypt 6.Sapienza Univ Rome, Res Ctr Nanotechnol Appl Engn, I-00185 Rome, Italy |
| 推荐引用方式 GB/T 7714 | Kumar, Jai,Neiber, Rana R.,Nafady, Ayman,et al. Robust Electrochemical Sensors for Detection of Isoprenaline Using Hexagonal Co3O4 Nanoplates Embedded in Few-Layer Ti3C2Tx Nanosheets[J]. ACS APPLIED NANO MATERIALS,2022,5(8):11352-11360. |
| APA | Kumar, Jai.,Neiber, Rana R..,Nafady, Ayman.,Albaqami, Munirah D..,Soomro, Razium Ali.,...&Karakus, Selcan.(2022).Robust Electrochemical Sensors for Detection of Isoprenaline Using Hexagonal Co3O4 Nanoplates Embedded in Few-Layer Ti3C2Tx Nanosheets.ACS APPLIED NANO MATERIALS,5(8),11352-11360. |
| MLA | Kumar, Jai,et al."Robust Electrochemical Sensors for Detection of Isoprenaline Using Hexagonal Co3O4 Nanoplates Embedded in Few-Layer Ti3C2Tx Nanosheets".ACS APPLIED NANO MATERIALS 5.8(2022):11352-11360. |
入库方式： OAI收割
来源：过程工程研究所
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