中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 过程工程研究所
  3. 中国科学院过程工程研究所
In vitro and in vivo low-dose exposure of simulated cooking oil fumes to assess adverse biological effects

文献类型：期刊论文

作者Li, Shuangde1; Wang, Li2; Guan, Shanyue2; Zhou, Shuyun2; Chen, Yunfa1,3
刊名SCIENTIFIC REPORTS
出版日期2022-09-20
卷号12期号:1页码:11
ISSN号2045-2322
DOI10.1038/s41598-022-19558-x
英文摘要Cooking oil fumes (COFs) represent a major indoor environmental pollutant and exhibit potent mutagenic or carcinogenic health effects caused by containing various heterocyclic aromatic amines (HAAs) and long-chain aldehydes. Despite some evaluation of the cumulative exposure of COFs to cancer cells under high concentration were evaluated, their biological adverse effects with low-dose exposure to healthy cells had been inadequately investigated. Herein, we firstly scrutinized the three selected typically toxic compounds of heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 3,8-dimethylammidazo[4,5-f]quinoxalin-2-amine (MeIQx) and trans, trans-2,4-decadienal (TDA)) emitted from COFs. In vitro studies revealed that the PhIP, MeIQx and TDA aerosol particles were negligible toxicity to cancer cells (A549 and HepG-2) but strong cytotoxicity to normal healthy cells (HelF and L02) under 0.5-4 mu g/mL low dose exposure based on the reactive oxygen species (ROS) mechanism. In vivo studies demonstrated that PhIP caused significant lung and liver damage after exposure to PhIP for 30 days with mice. These results indicated the direct proof of healthy cell damage even at low-dose exposure to HAAs and aldehydes.
WOS关键词LUNG-CANCER ; CHINESE COOKING ; EMISSIONS ; PROLIFERATION ; GENOTOXICITY ; CARCINOGEN ; COMPOUND ; HAZARDS ; PATHWAY ; PHIP
资助项目Open Research Fund of State Key Laboratory of Multiphase Complex Systems[MPCS-2019-D-06] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2018062]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000857187000036
出版者NATURE PORTFOLIO
资助机构Open Research Fund of State Key Laboratory of Multiphase Complex Systems ; Youth Innovation Promotion Association of Chinese Academy of Sciences
源URL[http://ir.ipe.ac.cn/handle/122111/54667]  
专题中国科学院过程工程研究所
通讯作者Guan, Shanyue; Chen, Yunfa
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat Tech, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Li, Shuangde,Wang, Li,Guan, Shanyue,et al. In vitro and in vivo low-dose exposure of simulated cooking oil fumes to assess adverse biological effects[J]. SCIENTIFIC REPORTS,2022,12(1):11.
APA Li, Shuangde,Wang, Li,Guan, Shanyue,Zhou, Shuyun,&Chen, Yunfa.(2022).In vitro and in vivo low-dose exposure of simulated cooking oil fumes to assess adverse biological effects.SCIENTIFIC REPORTS,12(1),11.
MLA Li, Shuangde,et al."In vitro and in vivo low-dose exposure of simulated cooking oil fumes to assess adverse biological effects".SCIENTIFIC REPORTS 12.1(2022):11.

入库方式： OAI收割

来源：过程工程研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。