A 3D bioprinted decellularized extracellular matrix/gelatin/quaternized chitosan scaffold assembling with poly(ionic liquid)s for skin tissue engineering
文献类型：期刊论文
| 作者 | Xu, Jie1; Fang, Huan1; Su, Ya1; Kang, Yue2; Xu, Deli3; Cheng, Yuen Yee4; Nie, Yi5,6; Wang, Hong7; Liu, Tianqing1; Song, Kedong1 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2022-11-01 |
| 卷号 | 220页码:1253-1266 |
| ISSN号 | 0141-8130 |
| 关键词 | Antibacterial Hemostasis Skin tissue engineering Antibacterial Hemostasis Skin tissue engineering |
| DOI | 10.1016/j.ijbiomac.2022.08.149 |
| 英文摘要 | Currently, a suitable bioink for 3D bioprinting and capable of mimicking the microenvironment of native skin and preventing bacterial infection remains a major challenge in skin tissue engineering. In this study, we pre-pared a tissue-specific extracellular matrix-based bioink, and dECM/Gel/QCS (dGQ) 3D scaffold assembling with poly(ionic liquid)s (PILs) (dGQP) was obtained by an extrusion 3D bioprinting technology and dynamic hydrogen bonding method. The morphologies, mechanical properties, porosity, hydrophilicity, biodegradation, hemostatic effect, antibacterial ability, and biocompatibility of the hybrid scaffolds were characterized and evaluated. Re-sults showed that the rapid release (2 h) of PILs on the dGQP scaffold can quickly kill gram-negative (E. coli) and gram-positive (S. aureus) bacteria with almost 100 % antibacterial activity and maintained a stable sterile environment for a long time (7 d), which was superior to the dGQ scaffold. The hemostasis and hemolysis test showed that the dGQP scaffold had a good hemostatic effect and excellent hemocompatibility. In vitro cyto-compatibility studies showed that although the cell growth on dGQP scaffold was slow in the early stage, the cells proliferated rapidly since day 4 and had high ECM secretion at day 7. Overall, this advanced dGQP scaffold has a considerable potential to be applied in skin tissue engineering. |
| WOS关键词 | ANTIBACTERIAL ACTIVITY ; INJECTABLE HYDROGELS ; NANOFIBROUS MATS ; IONIC LIQUID ; WOUNDS |
| 资助项目 | National Natural Science Foundation of China[31670978/31971275] ; Fok Ying Tung Education Foundation[132027] ; State Key Laboratory of Fine Chemicals[KF1111] ; Fundamental Research Funds for the Central Universities[DUT22YG213/DUT22YG116/DUT21YG113] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000856858000002 |
| 资助机构 | National Natural Science Foundation of China ; Fok Ying Tung Education Foundation ; State Key Laboratory of Fine Chemicals ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/54671]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Song, Kedong |
| 作者单位 | 1.Dalian Univ Technol, Dalian R&D Ctr Stem Cell & Tissue Engn, State Key Lab Fine Chem, Dalian 116024, Peoples R China 2.Canc Hosp China Med Univ, Dept Breast Surg, 44 Xiaoheyan Rd, Shenyang 110042, Peoples R China 3.Shandong Wendeng Osteopath Hosp, Dept Radiol, Weihai 264400, Shandong, Peoples R China 4.Univ Technol Sydney, Fac Sci, Inst Biomed Mat & Devices, Sydney, NSW 2007, Australia 5.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Peoples R China 6.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China 7.Dalian Med Univ, Dept Orthopead, Dalian Municipal Cent Hosp, Dalian 116033, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Jie,Fang, Huan,Su, Ya,et al. A 3D bioprinted decellularized extracellular matrix/gelatin/quaternized chitosan scaffold assembling with poly(ionic liquid)s for skin tissue engineering[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2022,220:1253-1266. |
| APA | Xu, Jie.,Fang, Huan.,Su, Ya.,Kang, Yue.,Xu, Deli.,...&Song, Kedong.(2022).A 3D bioprinted decellularized extracellular matrix/gelatin/quaternized chitosan scaffold assembling with poly(ionic liquid)s for skin tissue engineering.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,220,1253-1266. |
| MLA | Xu, Jie,et al."A 3D bioprinted decellularized extracellular matrix/gelatin/quaternized chitosan scaffold assembling with poly(ionic liquid)s for skin tissue engineering".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 220(2022):1253-1266. |
入库方式： OAI收割
来源：过程工程研究所
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