Advances in Delivering Oxidative Modulators for Disease Therapy
文献类型：期刊论文
| 作者 | Yang, Wei2,3; Yue, Hua2,3; Lu, Guihong2; Wang, Wenjing2; Deng, Yuan1,2; Ma, Guanghui2,3; Wei, Wei2,3 |
| 刊名 | RESEARCH
 |
| 出版日期 | 2022-09-21 |
| 卷号 | 2022页码:24 |
| ISSN号 | 2096-5168 |
| DOI | 10.34133/2022/9897464 |
| 英文摘要 | Oxidation modulators regarding antioxidants and reactive oxygen species (ROS) inducers have been used for the treatment of many diseases. However, a systematic review that refers to delivery system for divergent modulation of oxidative level within the biomedical scope is lacking. To provide a comprehensive summarization and analysis, we review pilot designs for delivering the oxidative modulators and the main applications for inflammatory treatment and tumor therapy. On the one hand, the antioxidants based delivery system can be employed to downregulate ROS levels at inflammatory sites to treat inflammatory diseases (e.g., skin repair, bone-related diseases, organ dysfunction, and neurodegenerative diseases). On the other hand, the ROS inducers based delivery system can be employed to upregulate ROS levels at the tumor site to kill tumor cells (e.g., disrupt the endogenous oxidative balance and induce lethal levels of ROS). Besides the current designs of delivery systems for oxidative modulators and the main application cases, prospects for future research are also provided to identify intelligent strategies and inspire new concepts for delivering oxidative modulators. |
| WOS关键词 | ACUTE KIDNEY INJURY ; TUMOR MICROENVIRONMENT ; PHOTODYNAMIC THERAPY ; TRANSDERMAL DELIVERY ; BLACK PHOSPHORUS ; OXYGEN ; CANCER ; NANOPARTICLES ; ANTIOXIDANT ; DESIGN |
| 资助项目 | Beijing Natural Science Foundation[JQ21027] ; Beijing Natural Science Foundation[2202056] ; National Natural Science Foundation of China[U2001224] ; National Natural Science Foundation of China[U20A20361] ; National Natural Science Foundation of China[32030062] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000861652800001 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 资助机构 | Beijing Natural Science Foundation ; National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/54923]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Ma, Guanghui; Wei, Wei |
| 作者单位 | 1.Gen Hosp Chinese PLA, Med Ctr 4, Dept Orthoped, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Wei,Yue, Hua,Lu, Guihong,et al. Advances in Delivering Oxidative Modulators for Disease Therapy[J]. RESEARCH,2022,2022:24. |
| APA | Yang, Wei.,Yue, Hua.,Lu, Guihong.,Wang, Wenjing.,Deng, Yuan.,...&Wei, Wei.(2022).Advances in Delivering Oxidative Modulators for Disease Therapy.RESEARCH,2022,24. |
| MLA | Yang, Wei,et al."Advances in Delivering Oxidative Modulators for Disease Therapy".RESEARCH 2022(2022):24. |
入库方式： OAI收割
来源：过程工程研究所
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