Metal Cluster Triggered-Assembling Heterogeneous Au-Ag Nanoclusters with Highly Loading Performance and Biocompatible Capability
文献类型：期刊论文
| 作者 | He, Xiaoxiao1,2; Ma, Xiaohong3; Yang, Yujun4,5; Hu, Xi1,2; Wang, Teng1,2; Chen, Shiyue1,2; Mao, Xiang1,2 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2022-10-01 |
| 卷号 | 23期号:19页码:16 |
| 关键词 | Au-Ag NCs heterogeneous structures assembling drug carriers biocompatibility |
| DOI | 10.3390/ijms231911197 |
| 英文摘要 | In this work, we firstly report the preparation of heterogeneously assembled structures Au-Ag nanoclusters (NCs) as good drug carriers with high loading performance and biocompatible capability. As glutathione-protected Au and Ag clusters self-assembled into porous Au-Ag NCs, the size value is about 1.358 (+/- 0.05) nm. The morphology characterization revealed that the diameter of Au-Ag NCs is approximately 120 nm, as well as the corresponding potential ability in loading performance of the metal cluster triggered-assembling process. Compared with individual components, the stability and loading performance of heterogeneous Au-Ag NCs were improved and exhibit that the relative biocompatibility was enhanced. The exact information about this is that cell viability was approximately to 98% when cells were incubated with 100 mu g mL(-1) particle solution for 3 days. The drug release of Adriamycin from Au-Ag NCs was carried out in PBS at pH = 7.4 and 5.8, respectively. By simulating in vivo and tumor microenvironment, the release efficiency could reach over 65% at pH = 5.8 but less than 30% at pH = 7.2. Using an ultrasound field as external environment can accelerate the assembling process while metal clusters triggered assembling Au-Ag NCs. The size and morphology of the assembled Au-Ag NCs can be controlled by using different power parameters (8 W, 13 W, 18 W) under ambient atmosphere. Overall, a novel approach is exhibited, which conveys assembling work for metal clusters triggers into heterogeneous structures with porous characteristic. Its existing properties such as water-solubility, stability, low toxicity and capsulation can be considered as dependable agents in various biomedical applications and drug carriers in immunotherapies. |
| WOS关键词 | SILVER NANOCLUSTERS ; GOLD NANOCLUSTERS ; INDUCED EMISSION ; NANOPARTICLES ; DELIVERY ; ENHANCEMENT ; SENSORS ; PROBES |
| 资助项目 | Scientific and Technology Research program of Chongqing Municipal Education Commission[KJQN201900436] ; Science and Technology Planning Project of Yuzhong District, Chongqing, China[20200118] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000867755500001 |
| 资助机构 | Scientific and Technology Research program of Chongqing Municipal Education Commission ; Science and Technology Planning Project of Yuzhong District, Chongqing, China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/55019]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Mao, Xiang |
| 作者单位 | 1.Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China 2.Chongqing Med Univ, Coll Biomed Engn, Chongqing Key Lab Biomed Engn, Chongqing 400016, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China 4.Chongqing Med Univ, Key Lab Lab Med Diagnost, Minist Educ, Dept Lab Med,Chongqing Med Lab Microfluid, Chongqing 400016, Peoples R China 5.Chongqing Med Univ, SPRi Engn Res Ctr, Chongqing 400016, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Xiaoxiao,Ma, Xiaohong,Yang, Yujun,et al. Metal Cluster Triggered-Assembling Heterogeneous Au-Ag Nanoclusters with Highly Loading Performance and Biocompatible Capability[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(19):16. |
| APA | He, Xiaoxiao.,Ma, Xiaohong.,Yang, Yujun.,Hu, Xi.,Wang, Teng.,...&Mao, Xiang.(2022).Metal Cluster Triggered-Assembling Heterogeneous Au-Ag Nanoclusters with Highly Loading Performance and Biocompatible Capability.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(19),16. |
| MLA | He, Xiaoxiao,et al."Metal Cluster Triggered-Assembling Heterogeneous Au-Ag Nanoclusters with Highly Loading Performance and Biocompatible Capability".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.19(2022):16. |
入库方式： OAI收割
来源：过程工程研究所
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