A surfactant-free droplet based microfluidic technique for the fabrication of polymeric microspheres
文献类型：期刊论文
| 作者 | Zhang, Yanlin1,2; Wang, Yong3,4,5; Du, Guanshang1; Hu, Chaoquan1,3 |
| 刊名 | MATERIALS TODAY COMMUNICATIONS
 |
| 出版日期 | 2022-12-01 |
| 卷号 | 33页码:11 |
| 关键词 | Polymeric microspheres Surfactant-free Microfluidic PMMA PVC |
| DOI | 10.1016/j.mtcomm.2022.104389 |
| 英文摘要 | In this study, a general and facile surfactant-free droplet-based technique is proposed for fabricating polymeric microspheres. First, a polymer is dissolved in a water-immiscible solvent. With a microfluidic system, the polymer solution flow is segmented with a water stream by hydrodynamic focusing to generate droplets, which are subsequently de-solvated in an amphi-solvent-water mixture continuous phase through solvent diffusion. In such a continuous phase, the de-solvation is substantially faster than that in the conventional surfactant solution. As model examples, poly(methyl methacrylate) (PMMA) and poly(vinyl chloride) microspheres are fabricated from their solutions in ethyl acetate and cyclohexanone, respectively, with ethanol-water mixture as the continuous phase. Fabrication parameters, including the ethanol-to-water ratio of the continuous phase, flow rates, and polymer concentration, are investigated. The microspheres are characterized by scanning electron microscopy. The results reveal that the interfacial tension between the polymer solution and continuous phase, flow pattern of water in the continuous phase, and viscosity of the solvent for the polymer solution are principal factors determining the characteristics of the microspheres, including the sphericity, size, and morphology. In addition, at a high ethanol-to-water ratio in the continuous phase, nanoparticles of PMMA are obtained, but they tend to aggregate under the experimental conditions. |
| WOS关键词 | LOADED-PLGA MICROSPHERES ; PMMA-MICROSPHERES ; DEGRADATION ; FORMULATION ; SOLVENTS ; BEHAVIOR ; ACID |
| 资助项目 | National Natural Science Foundation of China ; [22178350] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000867521700002 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/55051]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zhang, Yanlin; Hu, Chaoquan |
| 作者单位 | 1.Zhongke Nanjing Inst Green Mfg Ind, Nanjing 211135, Peoples R China 2.Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia 3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Natl Engn Res Ctr Green Recycling Strateg Met Res, Inst Proc Engn, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Beijing 101400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yanlin,Wang, Yong,Du, Guanshang,et al. A surfactant-free droplet based microfluidic technique for the fabrication of polymeric microspheres[J]. MATERIALS TODAY COMMUNICATIONS,2022,33:11. |
| APA | Zhang, Yanlin,Wang, Yong,Du, Guanshang,&Hu, Chaoquan.(2022).A surfactant-free droplet based microfluidic technique for the fabrication of polymeric microspheres.MATERIALS TODAY COMMUNICATIONS,33,11. |
| MLA | Zhang, Yanlin,et al."A surfactant-free droplet based microfluidic technique for the fabrication of polymeric microspheres".MATERIALS TODAY COMMUNICATIONS 33(2022):11. |
入库方式： OAI收割
来源：过程工程研究所
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